Prophylactic effect of JTE-607 on LPS-induced acute lung injury in rats with CINC-1 inhibition

Abstract

These results indicate that JTE-607 has an inhibitory effect on LPS-induced rat lung inflammation in parallel with CINC-1 reduction. The effect of JTE-607 was suggested to be through direct inhibition of CINC-1 production from rat alveolar macrophages. JTE-607 may thus be efficacious in cytokine-mediated lung inflammation such as acute respiratory distress syndrome.

Mannose prevents lipopolysaccharide-induced acute lung injury in rats

“…In our study, pre-treatment with DXM alleviated infl ammation in the lung induced by LPS (as shown in Figs. 1-8), which is similar to the observation previously reported [18,19]. In the present study, we investigated the effects of mannose and three other hexose sugars on inhibition of LPS-induced ALI.…”

Effects of SA13353, a Transient Receptor Potential Vanilloid 1 Agonist, on Leukocyte Infiltration in Lipopolysaccharide-Induced Acute Lung Injury and Ovalbumin-Induced Allergic Airway Inflammation

“…Exposure of animals to LPS has been reported to induce neutrophil infiltration and inflammatory cytokines, provoking changes similar to those in ARDS and COPD (8). In the present study, SA13353 dose-dependently reduced the number of inflammatory cells in the BALF.…”

“…Experimental procedures were carried out with the approval of the Santen Animal Experimental Ethics Committee. For LPS-induced acute lung injury (8), water for injections containing 200 μg/ mL of LPS (E. coli 0111:B4; Sigma, St. Louis, MO, USA) was aerosolized in a nasal inhalation exposure chamber using an ultrasonic nebulizer (NE-U17; Omron, Kyoto). Rats, 8 weeks in age, were fasted for 18 h before LPS inhalation exposure for 60 min.…”

A Novel, Potent Dual Inhibitor of the Leukocyte Proteases Cathepsin G and Chymase

“…By way of an acute experimental model, LPS can be administered by inhalation to develop an inflammatory condition in the airways and lungs, characterized by excessive neutrophil influx (35). Rats were treated with aerosolized saline or 1 followed by the administration of LPS 30 min later, and the levels of inflammatory cells in the bronchoalveolar lavage were determined after 24 h (Fig.…”