Prophylactic Effect of Tadalafil on Bladder Function in a Rat Model of Chronic Bladder Ischemia

Nomiya, Masanori; Burmeister, David M.; Sawada, Norifumi; Campeau, Lysanne; Zarifpour, Mona; Keys, Tristan; Peyton, Charles C.; Yamaguchi, Osamu; Andersson, Karl‐Erik

doi:10.1016/j.juro.2012.07.141

Cited by 65 publications

(84 citation statements)

References 30 publications

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“…Thus, the increase of the locomotor activity in the pelvic venous congestion rats that was observed in our current study suggests that naftopidil may have both a capillary stabilizing action, and inhibit the extravascular leakage of stimulatory substances that act on the bladder. In the atherosclerosis-induced chronic bladder ischemia rat model, changes in the urinary frequency were shown to be associated with an increase of oxidative stress markers in the urine or bladder tissue (17,19). Furthermore, atherosclerosis-induced chronic ischemic bladder also decreased constitutive nitric oxide synthase (NOS) (20).…”

Section: Discussionmentioning

confidence: 99%

Naftopidil improves locomotor activity and urinary frequency in rats with pelvic venous congestion

Sugaya¹,

Nishijima²,

Kadekawa³

et al. 2016

Biomed. Res.

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The α1D/A receptor antagonist, naftopidil, inhibits micturition reflex by acting on various different sites. We examined the effects of naftopidil on bladder activity and changes in the induced urinary frequency using female rats with pelvic venous congestion (PC). Twenty-four female rats were divided into sham, PC, and PC/naftopidil groups. After anesthetizing rats in the PC and PC/naftopidil groups, the bilateral common iliac veins and uterine veins were ligated. Rats in the sham and PC groups were fed a standard diet, while rats in the PC/naftopidil group were fed diets containing 0.04% naftopidil. After 4 weeks of treatment, locomotor activity, urinary nitric oxide metabolites (NOx), continuous cystometry, and plasma monoamine measurements were performed. PC rats exhibited a decrease of locomotor activity, a shorter interval between bladder contractions on continuous cystometry, and decreased urinary NOx and plasma serotonin levels than the sham rats. The PC/naftopidil rats exhibited an increase of locomotor activity, a longer interval between bladder contractions, and increased urinary NOx and plasma serotonin levels. Therefore, naftopidil might improve bladder dysfunction induced by pelvic venous congestion due to several actions in the central nervous system and bladder tissue, as well as acting as an α1 blocker to cause pelvic venous dilation.Unilateral or bilateral ovarian vein incompetence can cause pelvic congestion syndrome, which induces chronic pain, irritable bladder, dysfunction of the pelvic organs, or vulval varices and varicose veins in the lower limbs (1, 5, 7). Our previous study demonstrated that chronic prostatitis and stress urinary incontinence were related to the existence of vena cava reflux caused by tricuspid regurgitation (28). When we examined a female case with pelvic congestion syndrome using external iliac venography, we found that pelvic venous congestion occurred with tricuspid regurgitation and without pelvic venous valves (25). Our previous studies have also demonstrated that ligation of the bilateral common iliac veins in male rats or ligation of the bilateral common iliac veins and uterine veins in female rats induced changes in the urinary frequency and low locomotor activity (30). As compared to the intact rats, these surgically altered rats exhibited a bladder blood flow decrease that was about 80% of the flow in the intact bladder. Therefore, pelvic venous congestion may be one of the causes of pelvic ischemia, and might be related to several lower urinary tract symptoms/diseases. When examining hypertension, the relevance of lower urinary tract symptoms and their association with hypertension need to be taken into consideration. Spontaneously hypertensive rats have been shown to have a significantly lower bladder capacity and voiding volume (24), and these rats also exhibit

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Section: Discussionmentioning

confidence: 99%

Naftopidil improves locomotor activity and urinary frequency in rats with pelvic venous congestion

Sugaya¹,

Nishijima²,

Kadekawa³

et al. 2016

Biomed. Res.

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“…33,34 Prevention of bladder wall ischemia may potentially lead to a lesser degree of detrusor hypertrophy and hence bladder dysfunction; new treatment approaches towards this direction are currently being studied. 35 These findings were recently confirmed in humans by Mcnab and colleagues, by using new imaging technologies. 36 The authors performed a study in which the changes in tissue oxygenation and hemodynamics of 14 asymptomatic and 6 subjects with LUTS, were monitored using near-infrared spectroscopy (NIRS).…”

Section: Adjustment To Bladder Wall Ischemiamentioning

confidence: 74%

Obstruction-induced alterations within the urinary bladder and their role in the pathophysiology of lower urinary tract symptomatology.

Komninos

Mitsogiannis

2014

CUAJ

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Cite as: Can Urol Assoc J 2014;8(7-8) AbstractBenign prostatic hyperplasia (BPH) is considered a frequent cause of bladder outlet obstruction (BOO) and lower urinary tract symptoms. This review addresses the bladder response to BOO and focuses on the alterations and biochemical adaptability of the bladder wall in the presence of hypoxia. A literature review of published articles has been performed, including both in vivo and in vitro studies on human and animal tissue.

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“…Repeated oral administration of tadalafil protects bladder function in a rat model of chronic bladder ischemia induced by iliac arterial endothelial injury (AI rats) (Nomiya et al, 2013). In that model, repeated oral administration of tadalafil at 2 mg/kg/day for eight weeks significantly ameliorates the reduced bladder function, including the decreased micturition interval, bladder capacity and voided volume, and the changes in bladder morphology and contractility, although changes in BBF were not described.…”

Section: Discussionmentioning

confidence: 99%

“…In that model, repeated oral administration of tadalafil at 2 mg/kg/day for eight weeks significantly ameliorates the reduced bladder function, including the decreased micturition interval, bladder capacity and voided volume, and the changes in bladder morphology and contractility, although changes in BBF were not described. We found that a single treatment with tadalafil improved the sustained decrease in BBF in 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 our O/E and C/R rat models, so that it is likely that in the AI rat study (Nomiya et al, 2013), tadalafil improved the ischemia, leading to the protection of bladder function.…”

Section: Discussionmentioning

confidence: 99%

Effect of a single treatment with tadalafil on blood flow in lower urinary tract tissues in rat models of bladder overdistension/emptying and abdominal aorta clamping/release

Yoshinaga

Kawai

Oka

et al. 2015

European Journal of Pharmacology

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Prophylactic Effect of Tadalafil on Bladder Function in a Rat Model of Chronic Bladder Ischemia

Cited by 65 publications

References 30 publications

<b>Naftopidil improves locomotor activity and urinary frequency in rats with pelvic venous </b><b>congestion </b>

<b>Naftopidil improves locomotor activity and urinary frequency in rats with pelvic venous </b><b>congestion </b>

Obstruction-induced alterations within the urinary bladder and their role in the pathophysiology of lower urinary tract symptomatology.

Effect of a single treatment with tadalafil on blood flow in lower urinary tract tissues in rat models of bladder overdistension/emptying and abdominal aorta clamping/release

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