Prophylactic Effectiveness of Budesonide Inhalation in Reducing Postoperative Throat Complaints

Abstract

Objective: To evaluate the efficacy of budesonide suspension inhalation in reducing the incidence and severity of postoperative sore throat (POST) and hoarseness induced by tracheal intubation.Methods: 120 patients scheduled for thyroid surgery with general anaesthesia were randomized into 3 groups. Group A received 200 mcg budesonide inhalation suspension (BIS) 10 min prior to the tracheal intubation and received the same treatment 6 h and 24 h after extubation. Group B received 200 mcg BIS 6 h and 24 h after extubation. Control group received the same scheduled treatment as Group A, but the BIS was replaced with 2 ml normal saline. The patients were evaluated for POST and hoarseness 1, 24 and 48h after extubation and the status of laryngopharynx was examined and recorded as well. Results:The incidences of post-operation complaints in three groups were 72.5%, 82.5% and 87.55% for POST, and 37.3%, 52.5% and 75% for hoarseness, respectively. There was no statistically significant difference in the incidence of POST between three groups. However, hoarseness occurred significantly less frequently in Group A in comparison to Group B and control group (P<0.05). One hour post extubation, Group A exhibited significantly less severe POST and hoarseness compared to the other two groups (P<0.05), which disappeared 24 h later. One hour after extubation both VAS scores of POST and hoarseness were significantly lower in Group A than those in the other two groups (P<0.05). The mucositis scores of laryngopharynx at 1,24 and 48 h post extubation were significantly lower in Group A compared to the other two groups (P<0.05). Conclusions:The prophylactic use of inhaled budesonide suspension significantly decreases the incidence and severity of sore throat and hoarseness after tracheal intubation. J o u rn al of A n e s th es ia & C li n ic a l Resea rc h

Post Operative Sore Throat : Incidence after nebulization with Ketamine, Lidocaine and Budesonide

“…The incidence was lower in budesonide group at 48 hrs as compared to other groups. It is thought that topical corticosteroids decrease irritation, inflammation, and edema in the upper airways as well as the incidence and severity of sore throat and cough (13).…”

“…The patients were familiarised with the concept of visual analogue scale (VAS) for pain assessment with 0 = no pain and 10 = worst possible pain in pre anaesthetic checkup. Pain was classified as no pain (VAS=0), mild (1-3), moderate (4-6) and severe (7)(8)(9)(10). The condition of laryngopharynx was assessed by an ENT surgeon on indirect laryngoscopy at interval of 1, 6 and 24 hrs using the signs of mucositis in laryngopharynx (8).…”

A Comparative Study of Three Nebulized Medications for the Prevention of Postoperative Sore Throat in the Pediatric Population

“…The inhalational route had the advantage of reduced systemic side effects compared to the parenteral route because of limited systemic absorption. A study performed by Chen et al [33] concluded that the use of prophylactic inhaled budesonide can decrease the incidence and severity of POST and hoarseness of the voice after general anesthesia among patients undergoing thyroid surgery.…”

A Comparative Study of Two Pneumatic Nebulizers for the Treatment of Chronic Obstructive Pulmonary Disease (COPD); pre and post modification with polypropylene membrane

“…It also has the advantages of rapid onset, good curative effect, convenient use, less side effects, etc., and has thus become one of the most commonly used methods for the treatment of respiratory diseases. [4,5] There are three types of medical nebulizers including the pneumatic nebulizer, the ultrasonic nebulizer, and the vibrating-mesh nebulizer. Oxygen delivery devices with a pneumatic nebulizer function are widely used in Japan [6] ,China [8] and the world [9] .…”

“…Aerosol inhalation is a commonly used method for the clinical treatment of acute exacerbation of COPD. [4,5] Pneumatic nebulizers are commonly used in clinics and are usually connected to the central oxygen supply system of the hospital; also called an oxygen nebulizer. [6] Pneumatic atomizer models are diverse, however, there are no literature reports on the use of pneumatic nebulizers with respect to drug wastage.…”