Prophylactic effects of trimethoprim-sulfamethoxazole in Toxoplasma-infected mice

Yh, Lee; Dy, Lee; Dw, Shin

doi:10.3347/kjp.1993.31.4.363

Cited by 2 publications

(1 citation statement)

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“…Drugs and Cu-BTC dosage administration: Except for group (2), all infected mice were administered 100 mg/kg Cu-BTC, NTZ [23] , NTZ@Cu-BTC, Antinal [24] , Antinal@Cu-BTC, Septrin [25] , and Septrin@Cu-BTC on the 2 nd day PI for seven days. Doses were given daily through stomach tubes one hour before meals.…”

Section: Animalsmentioning

confidence: 99%

Nano copper-organic framework as a delivery system to improve the efficiency of commercially available drugs for cryptosporidiosis: In vivo experimental study

Soliman,

Naguib,

Abd El-Razik

et al. 2023

Parasitologists United Journal

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Background: Considering low efficacy, and high toxicity of the commonly used drugs in cryptosporidiosis, in addition to the development of drug resistance, trial for a novel approach is required. Objective: To evaluate the efficacy of Nifuroxazide (Antinal), Trimethoprim-Sulfamethoxazole (Septrin), Nitazoxanide (NTZ), loaded-on copper-benzene tricarboxylate (Cu-BTC) metal organic frameworks (MOH) for treatment of Cryptosporidium-experimentally infected mice. Material and Methods: Ninety male Swiss albino mice were divided into nine groups. Except for the 1 st group (control negative), all mice were infected with 10 3 Cryptosporidium oocysts. Except for 2 nd group (infected non treated), the remaining groups of infected mice were administered the tested drugs 2 nd day post infection (PI) for 7 days. Daily stool examination for oocyst shedding from day 3 to 18 PI was conducted to evaluate drugs' efficacy. Furthermore, to confirm Cryptosporidium complete eradication, real time PCR (RT-PCR) was performed on stool samples collected after 3 weeks PI. Survival rate was also calculated for 3 weeks PI (at 7 th , 14 th and 21 st d) to detect drugs' efficacy. Besides, physical characterization and toxicity of Cu-BTC were performed before mice treatment. Results: Electron micrographs revealed 300-500 nm pyramidal crystals of Cu-BTC. Non-loaded Antinal, Septrin, and NTZ showed 67.2%, 62.2% and 76.6% reduction in oocyst shedding, while loaded drugs showed 88.4%, 66.7%, and 98.3% reduction, respectively. Additionally, RT-PCR revealed that the best treatment for cryptosporidiosis was NTZ

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Section: Animalsmentioning

confidence: 99%