Prophylactic multimodal antiemetic in women undergoing cesarean section under spinal anesthesia

Comparative safety of serotonin (5-HT3) receptor antagonists in patients undergoing surgery: a systematic review and network meta-analysis

“…After screening 7,608 citations, we reviewed 1,014 potentially relevant full-text articles and identified 115 primary publications [ 10 , 33 , 38 – 150 ] and five companion reports [ 151 – 154 ] (reporting on six studies) providing data on 27,787 patients that met our inclusion criteria (Fig. 1 ).…”

“…The network meta-analysis for arrhythmia included 31 RCTs with 6,623 patients [ 40 , 43 , 45 , 53 , 59 , 74 , 78 , 79 , 83 , 86 – 89 , 97 , 102 , 108 , 112 – 115 , 117 , 119 , 123 , 125 , 128 , 130 , 132 , 138 , 141 , 142 , 150 ]. The network geometry and included drugs can be found in Fig.…”

“…A subgroup analysis was conducted for 26 RCTs involving 4,878 patients in which the agents were administered during surgery [ 40 , 43 , 45 , 53 , 59 , 74 , 78 , 79 , 83 , 86 – 89 , 97 , 102 , 112 , 113 , 115 , 117 , 119 , 123 , 125 , 132 , 138 , 142 , 150 ]. The results were the same as for the primary analysis, except that significantly fewer patients of all ages receiving dolasetron experienced arrhythmia compared with placebo (OR 0.58, 95 % CI 0.36–0.93) and ramosetron (OR 0.38, 95 % CI 0.17–0.92) (Additional file 1 : Appendix 13).…”

Interventions for preventing nausea and vomiting in women undergoing regional anaesthesia for caesarean section

“…Of the 52 studies remaining, 41 (involving 5046 women), provided usable data for this review (Abouleish 1999; Apiliogullari 2007; Duman 2010; Biswas 2003; Caba 1997; Charuluxananan 2003; Cherian 2001; Chestnut 1987; Chestnut 1989; Duggal 1998; El-Deeb 2011; Gaiser 2002; Habib 2006; Harmon 2000; Harnett 2007; Ho 1996; Ho 2006; Huang 1992; Jaafarpour 2008; Kasodekar 2006; Kotelko 1989; Lussos 1992; Mandell 1992; Mukherjee 2006; Nortcliffe 2003; Owczarzak 1997; Pan 1996; Pan 2001; Pan 2003; Pecora 2009; Peixoto 2006; Phillips 2007; Rudra 2004a; Sahoo 2012; Shahriari 2009; Stein 1997; Tarhan 2007; Tzeng 2000; Ure 1999; Wang 2001; Wu 2007). Three studies reported data in conference proceedings only (Apiliogullari 2007; Gaiser 2002; Kasodekar 2006).…”

“…We wrote to the authors and obtained further data Risk of bias Bias Authors’ judgement Support for judgement Random sequence generation (selection bias) Low risk Computer-generated random number table. Allocation concealment (selection bias) Unclear risk Not described. Blinding (performance bias and detection bias)All outcomes Low risk “…double blind controlled trial…”, “The patients were unaware of to which group they were randomised. Nursing staff were blinded to randomisation process and selection of the drugs used in this study.” Incomplete outcome data (attrition bias)All outcomes High risk Women were excluded if they received intraoperative propofol “due to propofol’s known antiemetic properties” The number excluded were: Dimenhydrinate (Gp D) excluded 9/70 = 13%, Metoclopramide (Gp M) excluded 12/70 = 17%, placebo (Gp P) excluded 7/70 = 10% Selective reporting (reporting bias) Unclear risk We did not assess the trial protocol. Other bias Low risk No problems apparent. El-Deeb 2011…”