Prophylactic negative pressure wound dressings reduces wound complications following emergency laparotomies: A systematic review and meta-analysis

Influence of Closed-incision Negative Pressure Wound Therapy on Abdominal Site Complications in Autologous Breast Reconstruction

“…Wound dehiscence has been shown to cause significant morbidity, including decreased patient quality of life, prolonged hospital stays, and increased care costs. 17 , 27 , 31 – 42 Our finding is congruent with other studies examining ciNPWT in orthopedic trauma, 5 , 43 breast surgery, 11 , 14 , 15 , 44 abdominal wall reconstruction, 34 , 45 laparotomy, 46 , 47 ventral hernia repair, 48 and reviews combing multiple types of procedures. 36 , 41 , 45 , 49 – 52 However, results in the literature are mixed, and other studies do not show this relationship.…”

“…This contradicts several studies demonstrating decreased surgical site infection rates with ciNPWT. [5][6][7][8][9]11,13,14,30,33,36,41,[43][44][45][46][47][48][49][50][51][52][54][55][56][57][58][61][62][63][64][65][66][67][68][69][70][71][72][73][74][75][76] However, the occurrence of infection in DIEP flaps is infrequent, with a recent meta-analysis reporting a donor site infection rate of 4.79%. 77 Mechanistically, ciNPWT acts as a barrier that prevents contamination of the surgical site with bacteria before reepithelization, encourages drainage of excess interstitial fluid, increases lymphatic flow, improves blood flow, and induces angiogenesis, theoretically decreasing the risk of infection and expediting healing.…”

“…Similar to seroma, there is controversy here, with some studies reporting that ciNPWT can reduce the length of hospital stay for certain patients, 36,49,[63][64][65]70,71 and other studies reporting no effect. 5,47,56,57,66,80 Notably, it is worth considering that early discharge of select DIEP flap patients, as soon as the first and second postoperative days, has been demonstrated to be safe, and thus, the use of ciN-PWT may not be expected to influence length of stay. [81][82][83][84][85] There are several limitations to this study.…”

Biomimetic Materials for Skin Tissue Regeneration and Electronic Skin

“…The process of wound healing, hemostasis, antimicrobial treatment, adhesion, and the ability to monitor the wound's condition are all complex [39,40]. These technologies can accelerate wound healing in complex wounds and achieve wound contraction without scarring [41][42][43][44]. In recent years, there has been a growing need for improved wound management techniques due to factors such as an aging population and an increase in patients with diabetes [45,46].…”