2012
DOI: 10.1016/j.hrthm.2012.02.033
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Prophylactic pacemaker implantation in familial amyloid polyneuropathy

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Cited by 85 publications
(45 citation statements)
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“…The MNT rate of decline, with a yearly decline up to 40 times faster in Val107 FAP, was far higher in non‐Portuguese than in PortMet30 patients. This was mostly due to repercussions of motor impairment on gait but also to the consequences of cardiomyopathy in non‐Portuguese patients 26. Gait impairment and the need for walking assistance occurred earlier in non‐Portuguese patients than in our PortMet30 patients and in previously reported PortMet30 patients 9.…”
Section: Discussionmentioning
confidence: 43%
See 1 more Smart Citation
“…The MNT rate of decline, with a yearly decline up to 40 times faster in Val107 FAP, was far higher in non‐Portuguese than in PortMet30 patients. This was mostly due to repercussions of motor impairment on gait but also to the consequences of cardiomyopathy in non‐Portuguese patients 26. Gait impairment and the need for walking assistance occurred earlier in non‐Portuguese patients than in our PortMet30 patients and in previously reported PortMet30 patients 9.…”
Section: Discussionmentioning
confidence: 43%
“…Prophylactic cardiac pacing at inclusion or during follow‐up performed on the basis of the surface electrocardiogram (ECG) and the electrophysiological study, as previously described 26. The following parameters were taken into account: PR interval, QRS duration and morphology, the His to ventricle duration (HV interval), and the anterograde Wenckebach point.…”
Section: Methodsmentioning
confidence: 99%
“…The majority of arrhythmias necessitating PPM are high-degree conduction block, symptomatic bra-dycardia, and atrial fibrillation with slow ventricular responses. In a large series of patients with FAP V30M with conduction disturbances who underwent electrophysiology studies, prophylactic PPMs were implanted for HIS-ventricular (HV) interval ≥70 ms, >55 ms associated with fascicular block, first-degree atrioventricular block (AVB), or Wenckebach anterograde point ≤100 bpm [42]. Patients who did not receive a PPM were typically younger and had less severe cardiac involvement than those who received a PPM for a class I/IIa indications or prophylactically.…”
Section: Considerations For Pacemaker and Cardioverter–defibrillator mentioning
confidence: 99%
“…Prophylactic pacemaker implantation is a major issue and indicated in about 30% of patients FAP patients at the stage of clinically diagnosed neuropathy, when they are considered for LT or medical treatment. In a selection of 100 patients with TTR-FAP and abnormal electrophysiological study, prophylactic pacing prevented major cardiac events in 25% of the patients over a 45-month mean follow-up [57].…”
Section: Amyloid Cardiomyopathy Managementmentioning
confidence: 99%