Prophylactic Pharmacological Treatment of Chronic Daily Headache

Redillas, Carol; Solomon, Seymour

doi:10.1046/j.1526-4610.2000.00014.x

Cited by 69 publications

(46 citation statements)

References 68 publications

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“…Although there is evidence in favor of the inefficacy of citalopram in chronic headache [24,33], in our patients, this drug showed a clear-cut antidepressant activity but was not as effective as amitriptyline in preventing TTH or migraine attacks. Accordingly, in our study, amitriptyline was superior to citalopram in the prevention of migraine and TTH in patients with coexisting depression, while both drugs showed a similar efficacy in depression.…”

Section: Discussioncontrasting

confidence: 76%

Evaluation of the Prophylactic Efficacy of Amitriptyline and Citalopram, Alone or in Combination, in Patients with Comorbidity of Depression, Migraine, and Tension-Type Headache

Rampello

Alvano

Chiechio³

et al. 2004

Neuropsychobiology

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Antidepressants are used to treat chronic daily headache disorders such as migraine and chronic tension-type headache (TTH), which are often associated with depression and anxiety. Here, we studied the efficacy and tolerability of amitriptyline and citalopram, given alone or in combination, in patients with ‘triple’ comorbidity of depression, TTH, and migraine. Eighty-eight patients were enrolled in the study and randomly divided into two groups. The first group received amitriptyline and the second citalopram for 16 weeks. Patients were assessed at weeks 0, 4, 8, and 16. The two drugs were equally efficacious in relieving depressive symptoms, although amitriptyline was more efficacious than citalopram in reducing migraine and TTH attacks. Patients who did not respond to monotherapy (<30% of improvement in the clinical scores) were treated with a combination of the two drugs for 16 additional weeks. In these selected patients, the combined treatment produced a substantial improvement in depression, migraine and TTH without producing major side effects such as those commonly related to the ‘serotonergic’ syndrome. The results indicate that a combined therapy with amitriptyline and citalopram may be particularly beneficial for patients with TTH, migraine and comorbid depression that do not respond to monotherapy.

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Section: Discussioncontrasting

confidence: 76%

Evaluation of the Prophylactic Efficacy of Amitriptyline and Citalopram, Alone or in Combination, in Patients with Comorbidity of Depression, Migraine, and Tension-Type Headache

Rampello

Alvano

Chiechio³

et al. 2004

Neuropsychobiology

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show abstract

“…Since pathophysiological mechanisms in TTH are poorly understood and treatment options, perhaps with the exception of antidepressive drugs (14,15), are few, unrealistic expectations may even contribute to prolonged symptom duration. Additionally, a large placebo effect (16) and increased occurrence of psychiatric comorbidity in patients suffering from chronic TTH (17) suggest that psychophysiologica l mechanism at least in part plays a role.…”

Section: Discussionmentioning

confidence: 99%

Patient satisfaction with a neurological specialist consultation for headache

Bekkelund

Salvesen

2002

Scandinavian Journal of Primary Health Care

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“…The role of antidepressants in chronic headache with comorbid psychiatric illness, is supported by several studies. 26 We frequently use antidepressants combined with psychotherapies, such as stress management, behavior-relaxation therapy, biofeedback may be affective adjuvant treatment of transformed migraine. …”

Section: Resultsmentioning

confidence: 99%