Prophylactic role of taurine and its derivatives against diabetes mellitus and its related complications

Sarkar, Poulami; Basak, Priyanka; Ghosh, Sumit; Kundu, Mousumi; Sil, Parames C.

doi:10.1016/j.fct.2017.10.022

Cited by 59 publications

(37 citation statements)

References 167 publications

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“…During each enteral-hepatic cycle, about 95% of the liver-derived bile salts are reabsorbed to the liver. ASBT apical sodium-dependent bile salt/acid transporter (in ileal enterocytes), BA bile acids (unconjugated), BSEP bile salt export pump, CBA conjugated bile acids, Gly glycine, GlyT glycine transporters, M3 multidrug resistance protein-3, MBSL microbial bile salt hydrolases, NTCP Na + -taurocholate cotransporting polypeptide, OATP organic anion transporting polypeptide family, OSTα/β organic solute transporter subunit α/β, PD passive diffusion, Tau taurine, TauT taurine transporters taurine can ameliorate structural abnormalities of the pancreas (Santos-Silva et al 2015), while improving insulin production by pancreatic β-cells (Nakatsuru et al 2018) and whole-body insulin sensitivity in subjects with hyperglycemia (Sarkar et al 2017). This role of taurine in diabetic patients are highly significant, because they have a 25% lower concentration of taurine in plasma than normal subjects (Sak et al 2019) and that the number of type-2 diabetic patients is increasing globally (Willet et al 2019).…”

Section: Health Benefits Of Taurine Supplementationmentioning

confidence: 99%

Important roles of dietary taurine, creatine, carnosine, anserine and 4-hydroxyproline in human nutrition and health

2020

Amino Acids

352

192

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Taurine (a sulfur-containing β-amino acid), creatine (a metabolite of arginine, glycine and methionine), carnosine (a dipeptide; β-alanyl-l-histidine), and 4-hydroxyproline (an imino acid; also often referred to as an amino acid) were discovered in cattle, and the discovery of anserine (a methylated product of carnosine; β-alanyl-1-methyl-l-histidine) also originated with cattle. These five nutrients are highly abundant in beef, and have important physiological roles in anti-oxidative and antiinflammatory reactions, as well as neurological, muscular, retinal, immunological and cardiovascular function. Of particular note, taurine, carnosine, anserine, and creatine are absent from plants, and hydroxyproline is negligible in many plant-source foods. Consumption of 30 g dry beef can fully meet daily physiological needs of the healthy 70-kg adult human for taurine and carnosine, and can also provide large amounts of creatine, anserine and 4-hydroxyproline to improve human nutrition and health, including metabolic, retinal, immunological, muscular, cartilage, neurological, and cardiovascular health. The present review provides the public with the much-needed knowledge of nutritionally and physiologically significant amino acids, dipeptides and creatine in animal-source foods (including beef). Dietary taurine, creatine, carnosine, anserine and 4-hydroxyproline are beneficial for preventing and treating obesity, cardiovascular dysfunction, and ageing-related disorders, as well as inhibiting tumorigenesis, improving skin and bone health, ameliorating neurological abnormalities, and promoting well being in infants, children and adults. Furthermore, these nutrients may promote the immunological defense of humans against infections by bacteria, fungi, parasites, and viruses (including coronavirus) through enhancing the metabolism and functions of monocytes, macrophages, and other cells of the immune system. Red meat (including beef) is a functional food for optimizing human growth, development and health.

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Section: Health Benefits Of Taurine Supplementationmentioning

confidence: 99%

Important roles of dietary taurine, creatine, carnosine, anserine and 4-hydroxyproline in human nutrition and health

2020

Amino Acids

352

192

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“…Diabetic remediation by taurine has been reviewed previously (63,64). Its supplementation remediates diabetic pathologies, including retinopathy, neuropathy, nephropathy, cardiopathy, atherosclerosis, altered platelet aggregation, and endothelial dysfunction (65).…”

Section: Conditional Vitaminsmentioning

confidence: 99%

Prolonging healthy aging: Longevity vitamins and proteins

Ames¹

2018

Proc. Natl. Acad. Sci. U.S.A.

197

133

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It is proposed that proteins/enzymes be classified into two classes according to their essentiality for immediate survival/reproduction and their function in long-term health: that is, survival proteins versus longevity proteins. As proposed by the triage theory, a modest deficiency of one of the nutrients/cofactors triggers a built-in rationing mechanism that favors the proteins needed for immediate survival and reproduction (survival proteins) while sacrificing those needed to protect against future damage (longevity proteins). Impairment of the function of longevity proteins results in an insidious acceleration of the risk of diseases associated with aging. I also propose that nutrients required for the function of longevity proteins constitute a class of vitamins that are here named “longevity vitamins.” I suggest that many such nutrients play a dual role for both survival and longevity. The evidence for classifying taurine as a conditional vitamin, and the following 10 compounds as putative longevity vitamins, is reviewed: the fungal antioxidant ergothioneine; the bacterial metabolites pyrroloquinoline quinone (PQQ) and queuine; and the plant antioxidant carotenoids lutein, zeaxanthin, lycopene, α- and β-carotene, β-cryptoxanthin, and the marine carotenoid astaxanthin. Because nutrient deficiencies are highly prevalent in the United States (and elsewhere), appropriate supplementation and/or an improved diet could reduce much of the consequent risk of chronic disease and premature aging.

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“…By contrast, significant differences were observed in hydrolytic GABA, taurine (TAU), -aminobutyric acid, ANS, ethanolamine (ETN), and 1-MHIS content, with TAU and ETN content about fourfold higher in bovine colostrum than in human colostrum. Previous studies reported TAU involvement in important biological functions, such as osmoregulation, membrane stabilization, 45 digestion, and the endocrine and immune systems. 46 Analysis of the total amount of hydrolytic amino acids revealed levels of 4.2 g L −1 and 2.2 g L −1 in bovine and human colostrum respectively.…”

Section: Comparison Of 22 Non-proteinogenic Amino Acids In Bovine Andmentioning

confidence: 99%

Quantitative analysis of amino acids in human and bovine colostrum milk samples through iTRAQ labeling

et al. 2018

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Prophylactic role of taurine and its derivatives against diabetes mellitus and its related complications

Cited by 59 publications

References 167 publications

Important roles of dietary taurine, creatine, carnosine, anserine and 4-hydroxyproline in human nutrition and health

Important roles of dietary taurine, creatine, carnosine, anserine and 4-hydroxyproline in human nutrition and health

Prolonging healthy aging: Longevity vitamins and proteins

Quantitative analysis of amino acids in human and bovine colostrum milk samples through iTRAQ labeling

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