Prophylactic sclerotherapy in children with esophageal varices: Long-term results of a controlled prospective randomized trial

Gonçalves, Manoel Ernesto Peçanha; Cardoso, Sílvia Helena; Maksoud, João Gilberto

doi:10.1016/s0022-3468(00)90203-3

Cited by 148 publications

(115 citation statements)

References 26 publications

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“…Use of prophylactic EST children with portal hypertension had lower bleeding episodes (24%) compared to controls (42%) over a median follow-up of 4.5 years (Goncalves, 2000). But the evidence and experience in children is limited to support recommendation of prophylactic EST or EVL.…”

Section: Primary Prophylaxismentioning

confidence: 98%

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Extra Hepatic Portal Venous Obstruction in Children

Arora¹,

Das²

2012

Portal Hypertension - Causes and Complications

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Section: Primary Prophylaxismentioning

confidence: 98%

“…Most of these are gastroesophageal varices while a few are isolated gastric varices Arora, 1998;Poddar, 2004). Following eradication of esophageal varices, gastric varices become more evident with increase in risk of bleeding (Poddar, 2004;Goncalves, 2000).…”

Section: Variceal Bleedingmentioning

confidence: 99%

Extra Hepatic Portal Venous Obstruction in Children

Arora¹,

Das²

2012

Portal Hypertension - Causes and Complications

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“…The spectrum also varies from country to country. In the West, intrahepatic causes of portal hypertension are common in children, whereas in the East, portal hypertension in children is mainly due to extrahepatic portal venous obstruction [96][97][98][99][100][101][102][103]. Endoscopic screening is still the best option in children for detecting varices.…”

Section: Recommendationsmentioning

confidence: 99%

“…No wellestablished approaches exist for preprimary and early primary prophylaxis in children. At present, only a few studies have been reported on primary prophylaxis of variceal bleeding in children [101][102][103][104][105][106]. In one retrospective study, propanolol was used in children with portal hypertension for prevention of variceal bleeding [106].…”

Section: Recommendationsmentioning

confidence: 99%

Primary prophylaxis of gastroesophageal variceal bleeding: consensus recommendations of the Asian Pacific Association for the Study of the Liver

et al. 2008

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The Asian Pacific Association for the Study of the Liver (APASL) set up a Working Party on Portal Hypertension in 2002, with a mandate to develop consensus guidelines on various clinical aspects of portal hypertension relevant to disease patterns and clinical practice in the Asia-Pacific region. Variceal bleeding is a consequence of portal hypertension, which, in turn, is the major complication of liver cirrhosis. Primary prophylaxis to prevent the first bleed from varices is one of the most important strategies for reducing the mortality in cirrhotic patients. Experts predominantly from the Asia-Pacific region were requested to identify the different aspects of primary prophylaxis and develop the consensus guidelines. The APASL Working Party on Portal Hypertension evaluated the various therapies that have been used for the prevention of first variceal bleeding. A 2-day meeting was held on January 12 and 13, 2007, at New Delhi, India, to discuss and finalize the consensus statements. Only those statements that were unanimously approved by the experts were accepted. These statements were circulated to all the experts and were subsequently presented at the annual conference of the APASL at Kyoto, Japan, in March 2007.

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“…This is the cause of serious complications like rebleeding (up to 20%), esophageal stricture and perforation. 2,3 Stiegmann and Goff developed endoscopic variceal ligation (EVL) as an alternative to endoscopic sclerotherapy. 4 In adult practice, variceal ligation has been shown to be safer and more effective than sclerotherapy and is now the preferred endoscopic treatment for variceal hemorrhage in adults.…”

Section: Introductionmentioning

confidence: 99%