Prophylactic tranexamic acid in Cesarean delivery: an updated meta-analysis with a trial sequential analysis

Provinciatto, Henrique; Barbalho, Maria E.; da Câmara, Pedro M.; Donadon, Isabelle B.; Fonseca, Luiza M.; Bertani, Marina S.; Marinho, Alice D.; Sirena, Eduardo; Provinciatto, Alexandre; Amaral, Sara

doi:10.1007/s12630-024-02715-3

Can J Anesth/J Can Anesth

2024

DOI: 10.1007/s12630-024-02715-3

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Prophylactic tranexamic acid in Cesarean delivery: an updated meta-analysis with a trial sequential analysis

Henrique Provinciatto,

Maria E. Barbalho,

Pedro M. da Câmara

et al.

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Cited by 3 publications

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Extracorporeal membrane oxygenation and pregnancy

Wong,

Kodali,

Rex

2024

Best Practice & Research Clinical Anaesthesiology

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Extracorporeal membrane oxygenation and pregnancy

Wong,

Kodali,

Rex

2024

Best Practice & Research Clinical Anaesthesiology

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Utilisation de l’acide tranexamique en péripartum

Clavaud,

Bonnet

2024

Le Praticien en Anesthésie Réanimation

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Is tranexamic acid appropriate for all patients undergoing high-risk surgery?

Abad-Motos,

García-Erce,

Gresele

et al. 2024

Current Opinion in Critical Care

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Purpose of review Tranexamic acid (TXA), an antifibrinolytic agent, reduces surgical bleeding in a variety of procedures, such as cardiac, orthopedic, abdominal, and urologic surgery, cesarean section, and neurosurgery. However, there are surgical interventions for which its use is not yet widespread, and some caution persists because of concerns regarding thrombotic risk. The purpose of this review is to analyze the most recent evidence in various subgroups of surgical specialties and the association of TXA with thrombotic events and other side effects (e.g. seizures). Recent findings Recent clinical trials and meta-analyses have shown that the efficacy and safety vary according to the clinical context, timing of administration, and dose. Some reports found that TXA reduces major bleeding by 25% without a significant increase in thrombotic events. Summary Wider use of TXA has the potential to improve surgical safety, avoid unnecessary blood use, and save healthcare funds.

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Prophylactic tranexamic acid in Cesarean delivery: an updated meta-analysis with a trial sequential analysis

Cited by 3 publications

References 46 publications

Extracorporeal membrane oxygenation and pregnancy

Extracorporeal membrane oxygenation and pregnancy

Utilisation de l’acide tranexamique en péripartum

Is tranexamic acid appropriate for all patients undergoing high-risk surgery?

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