Prophylactic use of antithrombin III concentrate following surgery in congenital antithrombin III deficiency

Abstract

Antithrombin III is the major physiological inhibitor of thrombin, and congenital deficiency of antithrombin III is associated with increased risk of venous thrombosis either spontaneously or following trauma, surgery or pregnancy. The successful use of antithrombin III concentrate during and following surgery to prevent venous thrombosis is described in a previously asymptomatic man with familial antithrombin III deficiency.

Choice of anticoagulant in a congenital antithrombin III (AT III)-deficient patient with chronic renal failure undergoing regular haemodialysis

“…I11 deficiency, haemodialysis, anticoagulation, synthetic antithrombin preparation Since congenital antithrombin I11 (AT 111) deficiency is accompanied by a predisposition to thrombosis, anticoagulant therapy and substitution therapy with AT I11 concentrate have been performed to prevent thrombosis at the time of pregnancy, childbirth, operation and trauma (Hambley et al 1987). Such therapies are stopped whenever the risk of thrombosis becomes diminished or eliminated.…”