Prophylactic use of gabapentin for prevention of succinylcholine-induced fasciculation and myalgia

Pandey, Chandra Kant; Tripathi, Mukesh; Joshi, Gunjan; Karna, Sunaina Tejpal; Singh, Nirupama; Singh, Pushpa

doi:10.4103/0022-3859.93248

Cited by 28 publications

(24 citation statements)

References 30 publications

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“…6 The exact mechanism is unknown, but several theories have been suggested. 5,7 Werawatganon et al 8 demonstrated that ECT patients who were treated with succinylcholine had increased serum myoglobin levels after the treatment, which was associated with muscle damage. 5,7 Werawatganon et al 8 demonstrated that ECT patients who were treated with succinylcholine had increased serum myoglobin levels after the treatment, which was associated with muscle damage.…”

Section: Discussionmentioning

confidence: 99%

Does Rocuronium-Sugammadex Reduce Myalgia and Headache After Electroconvulsive Therapy in Patients With Major Depression?

Sarıçiçek¹,

Şahin²,

Bülbül³

et al. 2014

The Journal of ECT

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Section: Discussionmentioning

confidence: 99%

Does Rocuronium-Sugammadex Reduce Myalgia and Headache After Electroconvulsive Therapy in Patients With Major Depression?

Sarıçiçek¹,

Şahin²,

Bülbül³

et al. 2014

The Journal of ECT

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“…Pre-treatment with diclofenac [1] , ketorolac [2] , calcium [3] , diazepam [4] , lignocaine [5] , magnesium [6] , small dose of succinylcholine as self-taming [7] , atracurium [8] , rocuronium [9] , cisatracurium [10] , remifentanyl [11] , gabapentin [12] , d-tubocurare [13] , pancuronium [14] , vecuronium [15] etc. have been tried to reduce or prevent succinylcholine induced fasciculations and myalgia but, none of them were thoroughly successful.…”

Section: Discussionmentioning

confidence: 99%

Usefulness of propofol to prevent succinylcholine induced fasciculations and myalgia, a comparison with thiopentone sodium as an induction agent

Parmar¹,

Vyas²,

Sheikh³

2013

Int J Med Sci Public Health

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Background: Succinylcholine induced fasciculations and myalgia may be a source of greater distress to the patient than the surgical pain. Aims & Objective: This study was designed to see if propofol offered any protection against succinylcholine induced fasciculations and myalgia compared with thiopentone sodium. Material and Methods: This prospective, randomized study was conducted in a teaching and tertiary care hospital. The study included 99 adult patients scheduled to undergo general anaesthesia for elective surgery. The patients were allocated randomly and equally into Group P1, P2 and T. Anaesthesia was induced in group P1 with propofol 2.5 mg/kg, group P2 with propofol 3.5 mg/kg and group T with thiopentone sodium 5 mg/kg. Tracheal intubation was facilitated by administration of intravenous succinylcholine 2 mg/kg. Incidence and severity of fasciculations were recorded. Anaesthesia was maintained with 50% Nitrous oxide in oxygen, Isoflurane and Vecuronium bromide. At the end of surgery, neuromuscular blockage is reversed and patients were extubated. All the patients were assessed at 6, 12 and 24 hours postoperatively to evaluate the incidence and severity of myalgia. Anova test was applied for quantitative data and Chi-square test for qualitative data. P value < 0.05 was taken as significant. Results: The demographic data of patients of the three groups were comparable. The total incidence of fasciculations were 25(75.76%), 16(48.48%) and 26(78.79%) in group P1, P2 and T respectively (p<0.001). Total score of fasciculations was 44(44.44%), 22(22.22%) and 53(53.54%) in group P1, P2 and T respectively. The severity of fasciculations was reduced more in group P2 than group P1 and T (p=0.0006). The total incidence of myalgia were 19(57.57%), 10(30.3%) and 23(69.7%) in group P1, P2 and T respectively (p<0.001). Total score of myalgia was 35(35.35), 18(18.18) and 45 (45.45) in group P1, P2 and T respectively. The severity of myalgia was reduced more in group P2 than group P1 and T (p<0.001). There was no correlation between fasciculations and myalgia in the present study (Pearson's r correlation, r =-0.139). Conclusion: Propofol 3.5 mg/kg in comparison with propofol 2.5 mg/kg and thiopentone sodium 5 mg/kg is effective in reducing the incidence and severity of succinylcholine induced fasciculations and myalgia.

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“…Succinylcholine, a depolarizing muscle relaxant with unique properties of rapid onset and short duration of action. 1 It also seems to be a popular muscle relaxant for ambulatory anesthesia and short surgical procedures. 2 It is regularly used by 69% of anesthesiologists and in 97% of emergency surgeries in Europe and the USA for adults.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Prophylactic Effect of Intramuscular Diclofenac Sodium for Prevention of Succinylcholine-Induced Myalgia

Hossain¹,

Rahman²,

Islam³

et al. 2019

KYAMC j.

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Background: Succinylcholine a depolarizing muscle relaxant with rapid onset, predictable course and short duration of action is associated with myalgia. Objectives: To assess the efficacy of intramuscular injection of diclofenac sodium in preventing succinylcholine-induced myalgia. Materials and Methods: Eighty healthy adults scheduled for elective surgery under general anesthesia were enrolledin a double-blind study and randomly allocated into two groups of forty patients. Patients in Group I (diclofenacgroup) were pretreated with inj. diclofenac 75 mg deep intramuscularly into gluteal region one hour prior to induction of anesthesia, while patients in Group II (saline group) received an equivalent volume of saline inj. in same site. Anesthesia was induced in both groups with fentanyl 1.5 mcg/kg, propofol 2.0 mg/kg and succinylcholine1.5 mg/kg. Postoperative myalgia was assessed 24 hours after induction and graded as nil, mild, moderate, or severe. Results:The demographic data for both groups were comparable (p > 0.05). Postoperative myalgia was recorded at 24 hours after induction in diclofenac group with twelve (30%) patients and 24 (60%) patients in normal saline (control) group respectively (p < 0.05). Conclusion: Prophylactic use of intramuscular injection of diclofenac is effective in the prevention of postoperative myalgia KYAMC Journal Vol. 10, No.-1, April 2019, Page 35-38

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Prophylactic use of gabapentin for prevention of succinylcholine-induced fasciculation and myalgia

Abstract: Prophylactic use of gabapentin 600 mg in laparoscopic cholecystectomy decreases the incidence and severity of myalgia and fentanyl consumption.

Cited by 28 publications

References 30 publications

Does Rocuronium-Sugammadex Reduce Myalgia and Headache After Electroconvulsive Therapy in Patients With Major Depression?

Does Rocuronium-Sugammadex Reduce Myalgia and Headache After Electroconvulsive Therapy in Patients With Major Depression?

Usefulness of propofol to prevent succinylcholine induced fasciculations and myalgia, a comparison with thiopentone sodium as an induction agent

Evaluation of Prophylactic Effect of Intramuscular Diclofenac Sodium for Prevention of Succinylcholine-Induced Myalgia

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