Prophylactic use of Mepitel Film prevents radiation-induced moist desquamation in an intra-patient randomised controlled clinical trial of 78 breast cancer patients

Herst, Patries M.; Bennett, N.C.; Sutherland, A.E.; Peszynski, R.I.; Paterson, Dean B.; Jasperse, Marieke

doi:10.1016/j.radonc.2014.01.005

Cited by 97 publications

(137 citation statements)

References 24 publications

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“…Mepitel Film also showed promise as a preventative barrier product for reducing moist desquamation rates 77. Due to the inherent physically apparent differences between the barrier films and creams, blinding of patients or physicians is not possible.…”

Section: Evidence For Radiation Dermatitis Preventionmentioning

confidence: 99%

Acute radiation dermatitis in breast cancer patients: challenges and solutions

Kole¹,

Kole²,

Moran³

2017

BCTT

102

106

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Nearly all women who receive radiotherapy (RT) for breast cancer experience some degree of radiation dermatitis. However, evidence describing the appropriate management of radiation dermatitis is often lacking or contradictory. Here, we summarize the available literature regarding radiation dermatitis causes, the presentation and timing of symptoms, methods for dermatitis assessment and prevention, and review evidence-based management strategies.

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Section: Evidence For Radiation Dermatitis Preventionmentioning

confidence: 99%

Acute radiation dermatitis in breast cancer patients: challenges and solutions

Kole¹,

Kole²,

Moran³

2017

BCTT

102

106

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“…However, a recent phase 3 trial did not show a significant difference for the management of RT skin reactions between an oil-based emulsion and an aqueous cream (27). In addition, measurements of bolus effect from silicone dressing were thought to be negligible when silicone film thickness was 0.12 mm, which we expect would be a greater thickness than emu oil residue (24). On the other hand, given that the skin is a target in some settings such as postmastectomy breast irradiation, there is some concern that agents that decrease skin reaction could interfere with the efficacy of RT.…”

Section: Discussionmentioning

confidence: 75%

“…In a recently reported study, Safetac-based soft silicone dressings (Mepitel film) were shown by Herst et al (24) to reduce the incidence of moist desquamation and to reduce skin reaction severity when used prophylactically in a cohort of postmastectomy and nonmastectomy patients. Previous clinical trials suggested that silicone dressings provide mechanical protection from trauma to the sublethally damaged basal skin layer, allowing tissue to repair the daily damage caused by RT.…”

Section: Discussionmentioning

confidence: 99%

“…It provides additional data in addition to provider-observed assessments that reflect the patient's lived experience. The Radiation-Induced Skin Reaction Assessment Scale (RIS-RAS) (22) also incorporates a professional assessment scale and a patient-rated symptom scale and has been used successfully to measure the observer-based and patient-based skin reaction in several recent trials (23)(24)(25)(26). Because the Skindex-16 does not include a professional assessment, the STAT was also used in this study.…”

Section: Discussionmentioning

confidence: 99%

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Double-Blind, Placebo-Controlled Pilot Study of Processed Ultra Emu Oil Versus Placebo in the Prevention of Radiation Dermatitis

Rollmann

Novotny

Petersen

et al. 2015

International Journal of Radiation Oncology*Biology*Physics

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“…A systematic review published in 2006 by the Cancer Care Ontario Supportive Care Guidelines Group concluded there was insufficient evidence to support the use of any topical agent. A systematic review published in 2010 reported that topical corticosteroids and hyaluronic acid might be of some benefit, which was validated for corticosteroids, but the evidence was inconsistent for hyaluronic acid and trolamine [16].…”

Section: Discussionmentioning

confidence: 99%

Safety and Efficacy of PTCTS Cosmetic Gel: Study on Human Radiodermatitis Lesions

Graziani¹,

Eyll²,

Fristachi³

et al. 2015

CRCM

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Radiodermatitis is a constant complication after radiotherapy with no efficient drug for prevention and treatment. Its physiopathology is complex, possibly related to injury of epidermis and endothelial cells from the basal layer by radiolysis, overproduction of free radicals, pro-inflammatory cytokines, and inflammation. PTCTS gel is an after sun cosmetic gel composed by antioxidative plant extract rich in natural nanoparticles and thermal water (Complex A) and recombinant protein of Trypanosoma cruzi transialidase (Complex B), with high anti-oxidative and antiapoptotic effects, presenting anti-aging and healing cutaneous properties. Objective: To study the safety and efficacy of PTCTS gel for topic use in volunteer subjects with healthy skin, and in patients with radiodermatitis, in different concentrations of Complexes A and B. Material and Methods: The project was approved by the Ethical Committee of Arnaldo Vieira de Carvalho Institute, Sao Paulo, Brazil. The individuals were submitted to laboratorial toxicity study through tests for liver and kidney function, levels of blood glucose and blood count before and after 7 days of PTCTS application. We studied two groups: GI-22 volunteers with healthy skin, presenting articular or skeletal muscle pain and GII-38 patients in radiotherapy for breast or head and neck cancer, with radiodermatitis grade 2 or 3. The patients were evaluated before and after 1.0 ml/cm 2 PTCTS gel application, twice a day. We tested Complex B in four different concentrations, and Complex A concentrations varied inversely. Results: No irritation signs were observed in GI nor GII group, 64% of GI had important decrease in the intensity of the muscular or articular pain, and 99% of GII showed regression of radiodermatitis, all exhibiting relief of pain. No patient presented hematologic, renal or hepatic toxicity. Conclusion: PTCTS cosmetic gel is a safe option for radiodermatitis treatment, with no side effects or laboratorial toxicity in different concentrations. This product presented excellent clinical results even if used diluted 4 times more than the original product and may be a good option for treatment of radiodermatitis. Further studies may show if it is also indicated in the prevention of the lesion, and if it is better than products containing corticoids. S. R. Graziani et al.328

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Prophylactic use of Mepitel Film prevents radiation-induced moist desquamation in an intra-patient randomised controlled clinical trial of 78 breast cancer patients

Cited by 97 publications

References 24 publications

Acute radiation dermatitis in breast cancer patients: challenges and solutions

Acute radiation dermatitis in breast cancer patients: challenges and solutions

Double-Blind, Placebo-Controlled Pilot Study of Processed Ultra Emu Oil Versus Placebo in the Prevention of Radiation Dermatitis

Safety and Efficacy of PTCTS Cosmetic Gel: Study on Human Radiodermatitis Lesions

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