Prophylaxis and management of antineoplastic drug induced nausea and vomiting in children with cancer

Totadri, Sidharth

doi:10.1016/j.phoj.2016.09.001

Cited by 6 publications

(6 citation statements)

References 24 publications

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“…In the CBT group, behavioral relaxation training was used, and chemotherapeutic children were induced repeatedly by psychotherapist to relax the whole body muscle through deep breathing and progressive muscle relaxation training with the objective to resist nausea, vomiting, and to perform bone marrow puncture in a relaxed state of mind and body. [27,28] Physical relaxation can relief the fear of venipuncture and blood sampling and enhance the ability of responding to anticipatory vomiting positively. Relaxation training enhances confidence in coping with side effects of chemotherapy, improves its self-coping efficacy, and relieves anxiety, tension and fear during treatment.…”

Section: Discussionmentioning

confidence: 99%

Effects of cognitive behavioral therapy on psychological adjustment in Chinese pediatric cancer patients receiving chemotherapy

Ping

Torres³

et al. 2019

Medicine

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Background: Cognitive behavioral therapy (CBT) has been widely used in pediatric cancer patients to promote psychological adjustment (PA). Considering the diversity of region and culture in China, its effect in Chinese population is not well defined. Therefore, our study is to explore the effect of CBT on improving PA in Chinese pediatric cancer patients receiving chemotherapy. Methods: One hundred four Chinese pediatric cancer patients receiving chemotherapy were divided into CBT group and control group randomly and equally. The resilience and negative mood were applied to evaluate the ability of psychological adjustment (PA). The Conner-Davidson Resilience Scale (CD-RISC) and depression anxiety stress scale (DASS) were employed to measure resilience and negative mood before and after intervention. The SPSS 22.0 software was used to analyze data. Results: Prior to the intervention, the ability of psychological adjustment between 2 groups showed no significant difference ( P > .05 for all). After intervention, the total CD-RISC score was significantly higher (56.09 ± 7.29 vs 44.75 ± 5.40), whereas the scores of depression (4.57 ± 2.94 vs 7.25 ± 4.25), anxiety (5.83 ± 3.07 vs 8.66 ± 4.92), stress (7.51 ± 4.33 vs 11.17 ± 4.25) were obviously lower in CBT group than those in the control group ( P < .05 for all). Moreover, the decline of negative mood score in Yolk sac tumor children was the most evident in CBT group. While the resilience changes of cancer children in stage III was most obvious. Conclusions: CBT can effectively help Chinese pediatric cancer patients modify distorted cognition to have a positive attitude towards cancer and chemotherapy. This treatment enhances resilience and relieves negative mood, which results in good psychological adjustment ability, especially in Yolk sac tumor and stage III. It has a beneficial effect on better treatment cooperation and high long-term quality of life.

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Section: Discussionmentioning

confidence: 99%

Effects of cognitive behavioral therapy on psychological adjustment in Chinese pediatric cancer patients receiving chemotherapy

Ping

Torres³

et al. 2019

Medicine

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“…Os agentes antineoplásicos podem ser classificados pelo seu potencial emetogênico em: mínimo (<10%), baixo (10-30%), moderado (30-90%) e alto (> 90%) (Smith et al, 2020;Totadri, 2016). Antineoplásicos considerados altamente emetogênicos incluem cisplatina em altas doses, carmustina, ciclofosfamida (em doses superiores a 1500g/m 2 ), dacarbazina, mecloretamina, estreptozocina e combinações de antraciclinas e fosfamida.…”

Section: Náuseas E Vômitos Induzidos Por Quimioterapiaunclassified

“…A dexametasona é um corticosteroide de ação prolongada, que age através da inibição da síntese de prostaglandinas no hipotálamo (Totadri, 2016). Quando administrada para a prevenção de NVIQ ela foi associada a menos efeitos adversos (Raghunath et al, 2020).…”

Section: Corticosteroidesunclassified

“…É importante ressaltar que o uso de dexametasona em pacientes com câncer deve ser monitorado, pois ela está associada a síndrome de lise tumoral no qual pode ocorrer distúrbios metabólicos desastrosos devido à destruição maciça das células malignas e liberação do seu conteúdo no espaço extracelular (Ames & Machovec, 2020). Os corticosteroides têm diversos efeitos adversos, como insônia, hiperglicemia, redução da densidade mineral óssea, imunossupressão e aumento do riscode infecções invasivas, portanto devem ser usados com cautela (Aldea et al, 2020;Minatogawa et al, 2020;Totadri, 2016).…”

Section: Corticosteroidesunclassified

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Farmacoterapia atual das náuseas e vômitos induzidos por antineoplásicos

Santos¹,

Gusmão

Oliveira³

et al. 2021

RSD

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As náuseas e vômitos induzidos por quimioterapia (NVIQ) são reações adversas à medicamentos comuns com o uso de antineoplásicos. Embora existam avanços na terapêutica profilática, o manejo de medicamentos antieméticos na prática clínica ainda tem sido um desafio a ser enfrentado. O objetivo do presente estudo foi buscar na literatura científica as principais terapias farmacológicas utilizadas nesta condição. Uma revisão sistemática foi realizada, no qual buscou-se artigos científicos indexados no PubMed, ScienseDirect e Web of Science, utilizando os seguintes descritores: chemotherapy; nausea; vomiting; drug therapy; serotonin 5-HT3 receptor antagonists, neurokinin-1 receptor antagonista. O grau de emetogenicidade causado pelos agentes antineoplásicos influencia diretamente no tratamento das NVIQ, que incluem os antagonistas dos receptores de serotonina (5-HT3), antagonistas dos receptores de neurocinina (NK-1). Este tratamento pode ser feito de forma individualizada, porém, caso ele não seja responsivo, é possível fazer a associação entre essas duas classes. Em casos mais complicados é indicado uma terapia tripla que é composta pela combinação de antagonistas dos receptores de 5-HT3 com antagonistas dos receptores de NK-1 e dexametasona. Portanto, a eficácia da terapia antiemética é aumentada nessa tríadequando comparados ao tratamento desses medicamentos de forma individualizada. Os antagonistas dos receptores de 5-HT3 de primeira geração são muito eficazes, contudo, a palonosetrona, de segunda geração, é mais eficaz e seguro. Uma formulação de netupitanto e palonosetrona, quando administrado juntamente com a dexametasona, tem sido uma boa opção para o tratamento de NVIQ.

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“…There is limited information on nausea/vomiting in hematologic diseases, particularly concerning CINV in ALL. Nausea is managed with prophylactic antiemetics (ondansetron, granisetron, or metoclopramide) administered intravenously or orally before and during chemotherapy [10,116,117].…”

Section: Cinv In Acute Lymphoblastic Leukemia Patientsmentioning

confidence: 99%

A multidisciplinary expert opinion on CINV and RINV, unmet needs and practical real-life approaches

Bossi

Airoldi

Spiriti

et al. 2020

Expert Opinion on Drug Safety

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Introduction: A range of combination chemotherapy regimens are currently used in clinical practice. However, international antiemetic guidelines often only categorize the emetogenic potential of single agents rather than the emetogenicity of combination chemotherapy regimens. To manage the nausea and vomiting induced by antineoplastic combinations, guidelines suggest antiemetics that are appropriate for the component drug with the highest emetogenic potential. Furthermore, antiemetic guidelines generally do not consider the influence of other factors, including individual patient characteristics, on the emetic effects of cancer treatments. Similarly, the emetogenic potential of radiotherapy is stratified only according to the site of radiation, while other factors contributing to emetic risk are overlooked. Areas covered: An Expert Panel was convened to examine unresolved issues and summarize the current clinical research on managing nausea and vomiting associated with combination chemotherapy and radiotherapy. Expert opinion: The panel identified the incidence of nausea and vomiting induced by multi-drug combination therapies currently used to treat cancer at different anatomic sites and by radiotherapy in the presence of other risk factors. Based on these data and the clinical experience of panel members, several suggestions are made for a practical approach to prevent or manage nausea and vomiting due to chemotherapy regimens and radiation therapy.

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Prophylaxis and management of antineoplastic drug induced nausea and vomiting in children with cancer

Cited by 6 publications

References 24 publications

Effects of cognitive behavioral therapy on psychological adjustment in Chinese pediatric cancer patients receiving chemotherapy

Effects of cognitive behavioral therapy on psychological adjustment in Chinese pediatric cancer patients receiving chemotherapy

Farmacoterapia atual das náuseas e vômitos induzidos por antineoplásicos

A multidisciplinary expert opinion on CINV and RINV, unmet needs and practical real-life approaches

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