Prophylaxis and treatment of chemo- and radiotherapy-induced oral mucositis – are there new strategies?

Karthaus, Meinolf; Rosenthal, Christoph; Ganser, Arnold

doi:10.1038/sj.bmt.1702024

Cited by 65 publications

(60 citation statements)

References 140 publications

(142 reference statements)

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“…8,30 Although the patients in our study who had fever preprocedure had a higher rate of CAI, this difference did not reach statistical significance, in agreement with published literature. 2 Poor nutritional status has a known association with hematologic abnormalities 31,32 and puts patients at a greater risk of chemotherapy-induced neutropenia. 10 In addition, it has a negative impact on wound healing.…”

Section: Discussionmentioning

confidence: 99%

Severe neutropenia at time of port insertion is not a risk factor for catheter‐associated infections in children with acute lymphoblastic leukemia

Junqueira

Connolly

Abla

et al. 2010

Cancer

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BACKGROUND:The objective of this study was to determine whether severe neutropenia on the day of port-a-catheter (PORT) insertion was a risk factor for catheter-associated infection (CAI) in children with acute lymphoblastic leukemia (ALL). METHODS: This was a retrospective study of children with ALL who had a PORT insertion between January 2005 and August 2008. Early ( 30 days) and late (>30 days) postprocedure complications were reviewed. The length of follow-up ranged between 7 months and 42 months. RESULTS: In total, 192 PORTs were inserted in 179 children. There were 43 CAIs (22%), and the infection rate was 0.35 per 1000 catheter-days. The CAI rate (15%) in children who had severe neutropenia on the day of the procedure did not differ statistically from the CAI rate (24%) in children who did not have severe neutropenia (P ¼ .137). Conversely, patients with severe neutropenia who had a CAI were more likely to have their PORT removed (P ¼ .019). The most common organisms to cause catheter removal were coagulase-negative Staphylococcus and Staphylococcus aureus. Patients with high-risk ALL had a statistically significant higher incidence of late CAI than patients with standard-risk ALL (P ¼ .012). Age (P ¼ .272), positive blood culture preprocedure (P ¼ 1.0), and dexamethasone use (P ¼ .201) were not risk factors for CAI. Patients who had an early CAI did not have a greater chance of having a late CAI. The catheter infection-free survival rate at 1 year was 88.6%. CONCLUSIONS: The current results indicated that severe neutropenia on the day of PORT insertion does not increase the risk of CAI in children with ALL. Cancer 2010;116:4368-75.

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Section: Discussionmentioning

confidence: 99%

Severe neutropenia at time of port insertion is not a risk factor for catheter‐associated infections in children with acute lymphoblastic leukemia

Junqueira

Connolly

Abla

et al. 2010

Cancer

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“…We have structured our manuscript-based thesis as follows: [6,[116][117][118]. Studies suggested the stages of progression of RIOM as initial hyperemia and erythema during the pre-ulcer phase where there is release of various pro-inflammatory cytokines from epithelial, vascular, and connective tissue cells at the site of tissue injury.…”

Section: Outlinementioning

confidence: 99%

Adipose mesenchymal stromal cells minimize and repair radiation-induced oral mucositis

et al. 2016

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“…Common potentially severe side-effects related to 5-FU include diarrhea, mucositis/stomatitis [3], and leucopenia [4]. Cardiotoxicity is a relatively uncommon sideeffect of 5-fluorouracil and capecitabine.…”

Section: Introductionmentioning

confidence: 99%

Two cases of 5-fluorouracil toxicity linked with gene variants in the DPYD gene

Öfverholm¹,

Arkblad²,

Skrtic³

et al. 2010

Clinical Biochemistry

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Objectives: Dihydropyrimidine dehydrogenase (DPD) is the initial rate-limiting enzyme in endogenous pyrimidine catabolism and is responsible for the reduction of the pyrmidine analog 5-fluorouracil (5-FU). DPD deficiency is known to cause potentially lethal toxicity in patients receiving 5-FU. Design and Methods:Restriction fragment length polymorphism (RFLP) and DNA sequence analysis were performed on genomic DNA and mRNA.Results: In 400 patients that were diagnosed with cancer and were eligible for 5-FU treatment, 14 patients were found to be heterozygous for the splice-site mutation DPYD IVS14+1G>A, which corresponds to a population frequency of 3.5%. Two novel variants in the DPYD gene were identified. The first case was heterozygous for DPYD c.1796T>C (p.M599T). In the second case, we observed heterozygosity for the splice-site mutation DPYD IVS14+17A>G. Conclusions:We report two new DPYD gene variants, of which DPYD c.1796T>C is potentially pathogenic, whereas DPYD IVS14+17A>G is suggested as a variant without clinical significance.

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Prophylaxis and treatment of chemo- and radiotherapy-induced oral mucositis – are there new strategies?

Cited by 65 publications

References 140 publications

Severe neutropenia at time of port insertion is not a risk factor for catheter‐associated infections in children with acute lymphoblastic leukemia

Severe neutropenia at time of port insertion is not a risk factor for catheter‐associated infections in children with acute lymphoblastic leukemia

Adipose mesenchymal stromal cells minimize and repair radiation-induced oral mucositis

Two cases of 5-fluorouracil toxicity linked with gene variants in the DPYD gene

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