Prophylaxis of Experimental Contrast Medium Injury To the Spinal Cord By Vasodepressor Drugs

Yerasimides, Theodore G.; Margolis, George; Ponton, H.J.

doi:10.1177/000331976301400803

Cited by 12 publications

(5 citation statements)

References 38 publications

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“…The potentiating action of a vasopressor drug confirms the authors' predictions based upon observations of the protective effect of vasodepressor substances, and supplies a vital link in our knowledge of the nature of contrast medium injury (64). The import of these observations is emphasized by the broad differences in toxicities of various contrast agents under these modifying influences.…”

Section: Discussionsupporting

confidence: 75%

“…IAvtralltlDog No. This paired experiment from a previous study(64) demonstrates the protective action of a vasodepressor drug against neurotoxic effects of roentgen contrast agents in the canine aortography model. A representative map of the arterial supply of the cord is presented, rather than the actual pattern of blood supply for each animal.…”

mentioning

confidence: 60%

“…This latter reaction had not been encountered in previous studies with contrast agents, where a mild depressor effect had been the common observation (42). The varying pressure responses to contrast agents with and without vasoactive drugs, are summarized elsewhere (64). Certain other features of these studies stand out.…”

Section: Resultsmentioning

confidence: 99%

“…Holding that all contrast agents were capable of producing a necrotizing lesion if they reached the vascular bed of organs in the mainstream of their flow in concentrations approaching the high initial level required for angiography, they initiated a series of studies exploring means of protecting recipient subjects (24,64). Information derived from these investigations would also provide insight into the mechanisms of tissue injury caused by these substances.…”

Section: George~iargolis and Theodore G Yerasimidesmentioning

confidence: 99%

“…The Levophed block may be explained on the basis of its depressant action upon the central nervous system (33,34,53). On the other hand, Papaverine and Arfonad, while offering strong protection from neurotoxic effect, demonstrated no ameliorating influence upon the convulsive response (64). On the basis of this observation attribution of the convulsive response to the direct irritative action of a contrast agent at the neuronal level consequent to damage of the blood brain barrier appears to be an oversimplified concept.…”

Section: George Margolis and Theodore G Yerasimidesmentioning

confidence: 99%

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Vasopressor Potentiation of Neurotoxicity in Experimental Aortography

Margolis¹,

Yerasimides²

1966

Acta Radiologica. Diagnosis

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In 1956 MARGOLIS and associates introduced a new experimental model (39,60) for the study of the pathogenesis of the injury to the nervous system produced by contrast media used in diagnostic angiology. Employing retrograde abdominal aortography in the dog, and using the spinal cord as the site of study they described, for the first time in experimental animals, the full evolution of the contrast medium lesion. From these observations it was manifest that existing concepts of the injury as a transient vascular disorder were no longer adequate and had to be revised to include a severe necrotizing effect.Continuing their studies with this model (41, 42), they described in association with the injury a severe irreversible disruption of the circulation of the cord, immediate in onset, and characterized by an abrupt arrest of the toxic injection mass, an immediate impairment of vascular permeability barriers, torpid blood flow with development of severe sludging, and a persistent elevation of vascular resistance in the area of injury. The changes took place in the absence of demonstrable vasospasm. These disturbances in vasomotion were so severe as to constitute, in their opinion, a formidable obstacle to any therapeutic 388 at Harvard Libraries on June 30, 2015 acr.sagepub.com Downloaded from

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Section: Discussionsupporting

confidence: 75%

mentioning

confidence: 60%

Section: Resultsmentioning

confidence: 99%

Section: George~iargolis and Theodore G Yerasimidesmentioning

confidence: 99%

Section: George Margolis and Theodore G Yerasimidesmentioning

confidence: 99%

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