Prophylaxis of Experimental Rabies with the Polyriboinosinic-Polyribocytidylic Acid Complex

Fenje, P; Postic, Boško

doi:10.1093/infdis/123.4.426

Cited by 37 publications

(9 citation statements)

References 12 publications

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“…The use of poly(I:C) has been shown to be highly effective in preventing rabies in mice and rabbits (5,8). The results reported in this paper further emphasize the efficacy of therapy with poly(I:C) alone in preventing rabies infection when given after exposure to virus, which is analogous to the condition under which most humans are treated.…”

Section: Resultssupporting

confidence: 54%

Post-Exposure Prophylaxis of Murine Rabies with Polyinosinic-Polycytidylic Acid and Chlorite-Oxidized Amylose

Harmon

Janis

Levy

1974

Antimicrob Agents Chemother

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Chlorite-oxidized amylose (COAM), polyinosinic-polycytidylic acid [poly(I:C)], and combinations of the two drugs were evaluated for their interferon-inducing properties and their ability to protect mice against rabies infection. Post-exposure administration of one or two doses (100 μg each) of poly(I:C) significantly protected mice against rabies infection. Pretreatment of mice with COAM 3 h before poly(I:C) stimulation resulted in an enhancement of the interferon response. However, the increased interferon titers were not reflected by increased protection against rabies infection over that achieved with poly(I:C) therapy alone. Therapy with COAM alone did not protect mice against rabies but, rather, was associated with enhanced mortality.

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Section: Resultssupporting

confidence: 54%

Post-Exposure Prophylaxis of Murine Rabies with Polyinosinic-Polycytidylic Acid and Chlorite-Oxidized Amylose

Harmon

Janis

Levy

1974

Antimicrob Agents Chemother

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“…New Zealand white rabbits of both sexes, purchased from a Toronto breeder, weighed approximately 1 kg each when injected with rabies virus. After injection, they were observed for 6 weeks as in previous studies (8,9). With the given strain of street virus, the encephalitic signs of disease were invariably followed by the death of rabbits in 2 to 3 days.…”

mentioning

confidence: 93%

Effect of Administered Interferon on Rabies in Rabbits

Postic¹,

Fenje²

1971

Applied Microbiology

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This study describes the effect of interferon on the survival of rabbits infected with a street strain of rabies virus. Interferon was prepared by collecting serum from rabbits injected with Newcastle disease virus and was characterized by biological and physicochemical methods. Rabbit serum interferon mixed and incubated with a suspension of rabies virus did not neutralize its infectivity. Rabbits were inoculated into the hind leg muscle with approximately 80 LD50 of virus. Interferon was administered intravenously or intramuscularly, or by both methods, in the same or opposite leg as virus. Mortality due to rabies was significantly reduced by the concurrent administration of 8 x 105 units of interferon divided between the site of virus inoculation and intravenously. There was less protection if 3 hr elapsed between the inoculation of virus and interferon. Treatment given 24 hr after infection did not prevent death but prolonged the incubation period.

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“…Antibody-enhancing adjuvant activity of both poly A : U [88] and polyribo I : C was demonstrated with rabies vaccine [89], along with reports of interferon induction in primates by polylysine/carboxymethylcellulose-stabilized poly I : C [90].…”

Section: Mechanistic Work By Mckinney and Davenportmentioning

confidence: 99%