Prophylaxis versus pre-emptive treatment for infective and inflammatory complications of surgical third molar removal: a randomized, double-blind, placebo-controlled, clinical trial with sustained release amoxicillin/clavulanic acid (1000/62.5mg)

Lacasa, J; Jiménez, Jasmina; Ferras, Vinícius Gonçalves; Bossom, M.; Solà-Morales, Oriol; Garcı́a-Rey, César; Aguilar, Lorenzo; Garau, Javier

doi:10.1016/j.ijom.2006.11.007

Cited by 91 publications

(107 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…[7][8][9][10]28 However, the use of prophylactic antibiotics and type of antibiotic used is controversial. Some studies have found that the routine provision of antibiotics does not provide any benefi t in the prevention of postoperative complications.…”

Section: Discussionmentioning

confidence: 99%

“…5,6 Variables that may contribute to the incidence and severity of postoperative complications include the length of operation, surgical techniques implemented, including fl ap design, irrigation and management of soft tissues, as well as the use of dressings, mouthwashes and prophylactic antibiotics. [7][8][9][10][11] Other factors that may infl uence the outcome include the patient's health status, age, gender, race and anxiety. 12,13 The degree of impaction of the tooth and pre-existing pathology and/or infection should also be taken into consideration as it may affect the outcome.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Experience in third molar surgery: an update

Jerjes¹,

Upile

Nhembe³

et al. 2010

Br Dent J

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Experience in third molar surgery: an update

Jerjes¹,

Upile

Nhembe³

et al. 2010

Br Dent J

View full text Add to dashboard Cite

“…Poeschl et al (2004) 17 in a prospective study of 528 impacted lower third molars surgeries, concluded that prophylactic antibiotic treatment does not contribute to a better wound healing, less pain or increased mouth opening and could not prevent cases of inflammatory problems after surgery. Lacasa et al (2007) 19 assessed the clinical efficacy of two schedules of amoxicillin/clavulanate versus placebo for mandibular third molar surgery through a randomized, double-blind clinical trial and observed that the antibiotic regimen was superior than placebo to control infection and to reduce pain after surgery. The present study observed that the use of antibiotics did not show a beneficial effect over pain's response, in accordance with the literature.…”

Section: Jcdp Pain Levels After Third Molar Surgical Removal: An Evalmentioning

confidence: 99%

Pain Levels after Third Molar Surgical Removal: An Evaluation of Predictive Variables

Bortoluzzi

Guollo²,

Capella³

2011

The Journal of Contemporary Dental Practice

View full text Add to dashboard Cite

Aim:The aim of this prospective study was to evaluate the pain course after surgical removal of third molars. Materials and methods:The sample consisted of 100 consecutive patients. Pain intensity was assessed by means of a visual analog scale (VAS).Results: At day 1, moderate and severe pain were observed predominantly in patients who had surgery in the mandible (p < 0.001) and for patients younger than 24 years (p = 0.009), while more patients who weekly consumed mate tea (Ilex paraguariensis) showed pain classified as none or light (p = 0.017). At day 2, the profile of pain moderate/severe was more prevalent for patients who had surgery in the mandible (p < 0.001) with the report of difficult surgery (p = 0.042) and with odontotomy performed (p = 0.033). In the third postoperative day, severe/moderate pain was associated with surgery in the mandible (p < 0.001) and with odontotomy (p = 0.021) and ostectomy (p = 0.028) performed, with report of long and difficult procedure (p = 0.023), surgeries which last more than sixty minutes (p < 0.026), and for those patients who developed postoperative inflammatory complications (p < 0.001). Conclusion:Higher pain complains could be expected for patients who have long and difficult mandibular third molar surgery characterized by odontotomy and ostectomy.Clinical significance: Pain after third molar surgery is a common sequele. It is indispensable for the dentists to be apt in handling and preventing it as far as possible and know possible variables that may influence or increase these pain levels. It can be a clinical advantage. Better understanding the pain characteristics may guide the dentist through preoperative decisions.

show abstract

“…Some studies connect surgical complications with cases with ostectomy (3,4,6) and with duration of surgical procedure (3). In this study these connections are not found.…”

Section: Discussionmentioning

confidence: 51%

“…It is considered a clean-contaminated procedure due to oral colonization by more than 400 aerobic and anaerobic species (3)(4)(5). Usual postoperative sequelae are pain, trismus and facial swelling.…”

Section: Introductionmentioning

confidence: 99%

Efficacy and safety comparison of two amoxicillin administration schedules after third molar removal. A randomized, double-blind and controlled clinical trial

Luaces-Rey¹,

Arenaz-Búa²,

Lopez-Cedrún-Cembranos³

et al. 2010

Med Oral

View full text Add to dashboard Cite

Objective: The aim of this comparative double-blind, prospective, randomized, clinical trial was to evaluate two amoxicillin administration patterns. The first was a short prophylactic therapy and the second a long postoperative regimen. Study Design: The study population consisted of 160 patients who underwent mandibular third molar extraction. Patients were randomized into two equal groups. In group 1, 2 grams of amoxicillin were administered 1 hour before the procedure and 1 gram 6 hours after surgery. In group 2, patients received 1 gram of amoxicillin 6 hours after surgery followed by 1 gram every 8 hour for 4 days. All patients received the same number of tablets thanks to the use of placebo pills. A total of 25 variables were evaluated, such as alveolitis, surgical infection, number of analgesic needed, subjective pain scale, post-surgical inflammation, consistency of the diet, axillary temperature and millimetres of mouth opening loss after the surgery. Results: No statistically significant post-operative differences were found within the recorded parameters between the groups. Conclusions: Postoperative 4-days amoxicillin therapy is not justified.

show abstract

Prophylaxis versus pre-emptive treatment for infective and inflammatory complications of surgical third molar removal: a randomized, double-blind, placebo-controlled, clinical trial with sustained release amoxicillin/clavulanic acid (1000/62.5mg)

Cited by 91 publications

References 16 publications

Experience in third molar surgery: an update

Experience in third molar surgery: an update

Pain Levels after Third Molar Surgical Removal: An Evaluation of Predictive Variables

Efficacy and safety comparison of two amoxicillin administration schedules after third molar removal. A randomized, double-blind and controlled clinical trial

Contact Info

Product

Resources

About