Propionate regulates tight junction barrier by increasing endothelial-cell selective adhesion molecule in human intestinal Caco-2 cells

Isayama, Kana; Rini, Dina Mustika; Yamamoto, Yuroku; Suzuki, Takuya

doi:10.1016/j.yexcr.2023.113528

Cited by 17 publications

(10 citation statements)

References 26 publications

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“…40 Butyric acid and propionic acid have been demonstrated to increase the expression of tight junctions and MUC2 and to promote the proliferation of epithelial cells. 41,42 SCFAs have been associated with intestinal tight junctions, mucins and inflammation, consistent with the present study. 43 Meanwhile, SCFAs exerts beneficial effects on glucose homeostasis and insulin sensitivity.…”

Section: Discussionsupporting

confidence: 92%

“…Metabolites produced by gut microbiota such as SCFAs have an important role in regulating immune response, energy metabolism and nutrient absorption 40 . Butyric acid and propionic acid have been demonstrated to increase the expression of tight junctions and MUC2 and to promote the proliferation of epithelial cells 41,42 . SCFAs have been associated with intestinal tight junctions, mucins and inflammation, consistent with the present study 43 .…”

Section: Discussionsupporting

confidence: 87%

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Lead exposure aggravates glucose metabolism disorders through gut microbiota dysbiosis and intestinal barrier damage in high‐fat diet‐fed mice

Wang,

Gao,

Huo

et al. 2023

J Sci Food Agric

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BACKGROUNDLead (Pb) is an ancient toxic metal and is still a major public health issue. Our previous study found that Pb exposure promotes metabolic disorders in obese mice, but the molecular mechanisms remain unclear. The present study explored the effects of Pb exposure on glucose homeostasis in mice fed a normal diet (ND) and high‐fat diet (HFD) from the perspective of gut microbiota.RESULTSPb exposure had little effect on glucose metabolism in ND mice, but exacerbated hyperglycemia and insulin resistance, and impaired glucose tolerance in HFD mice. Pb exposure impaired intestinal tight junctions and mucin expression in HFD mice, increasing intestinal permeability and inflammation. Moreover, Pb exposure altered the composition and structure of the gut microbiota and decreased short‐chain fatty acids (SCFAs) levels in HFD mice. Correlation analysis revealed that the gut microbiota and SCFAs were significantly correlated with the gut barrier and glucose homeostasis. Furthermore, the fecal microbiota transplantation from Pb‐exposed HFD mice resulted in glucose homeostasis imbalance, intestinal mucosal structural damage and inflammation in recipient mice. However, Pb did not exacerbate the metabolic toxicity in HFD mice under depleted gut microbiota.CONCLUSIONThe findings of the present study suggest that Pb induces impairment of glucose metabolism in HFD mice by perturbing the gut microbiota. Our study offers new perspectives on the mechanisms of metabolic toxicity of heavy metals and demonstrates that the gut microbiota may be a target of action for heavy metal exposure. © 2023 Society of Chemical Industry.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 87%

Lead exposure aggravates glucose metabolism disorders through gut microbiota dysbiosis and intestinal barrier damage in high‐fat diet‐fed mice

Wang,

Gao,

Huo

et al. 2023

J Sci Food Agric

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“…Moreover, bacterially produced short-chain fatty acids, butyrate, and propionate can regulate gut permeability [23,24] and enhance gut hormone release of glucagon-like peptide 1 (GLP-1), glucagon-like peptide 2 (GLP-2), and peptide YY (PYY), thereby affecting insulin secretion and glucose homeostasis [25][26][27].…”

Section: Accepted Manuscriptmentioning

confidence: 99%

“…For example, the levels of anti-inflammatory cytokines IL-10 and IL-22, can be increased by certain microbes and have been shown to protect against insulin resistance in muscles and improve insulin sensitivity. Moreover, short-chain fatty acids, butyrate, and propionate produced by bacteria can regulate gut permeability 23 24 and enhance gut hormone release of glucagon-like peptide 1 (GLP-1), glucagon-like peptide 2 (GLP-2), and peptide YY (PYY), thereby affecting insulin secretion and glucose homeostasis 25 26 27 .…”

Section: Introductionmentioning

confidence: 99%

Impact of Physiological Fluctuations of Sex Hormones During the Menstrual Cycle on Glucose Metabolism and the Gut Microbiota

Schieren,

Koch,

Pecht

et al. 2024

Exp Clin Endocrinol Diabetes

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Diabetes mellitus is one of the most prevalent chronic diseases in the world. Previous studies have shown differences in glucose metabolism between males and females. Moreover, difficulties in medication adherence have been reported in females with type 2 diabetes. These observations are believed to be caused by fluctuations in sex hormone concentrations during the menstrual cycle. Furthermore, gut microbiota is linked to female host metabolism and sex hormone production. Understanding the interactions between fluctuating hormone concentrations during the menstrual cycle, gut microbiota as well as glucose metabolism in humans is of great relevance because of the increasing prevalence of diabetes and the consequent need to expand preventive efforts. To determine and summarize the existing evidence, deduce future research needs to maintain female health, and investigate the relationship between the physiological menstrual cycle and glucose metabolism, a literature search was performed. Surprisingly, the relationship between variations in the course of the menstrual cycle and glucose metabolism has been examined in healthy female subjects using an OGTT or IVGTT already in studies from 1967 to 2020; however, the overall number of studies is rather small. The results are contradictory, as some studies have detected differences in glucose concentrations depending on the different cycle phases, whereas others have not. Moreover, some studies have shown lower glucose levels in the follicular phase than in the luteal phase, whereas another study detected lower glucose levels in the luteal phase. Data on gut microbiota in relation to the menstrual cycle are limited. Conflicting results exist when examining the effect of hormonal contraceptives on the gut microbiota and changes in the course of the menstrual cycle. However, the results indicate that the menstrual cycle, especially fluctuating sex hormones, might have an impact on the composition of the gut microbiota. In conclusion, the menstrual cycle may affect the composition of the gut microbiota as well as glucose metabolism. These results indicate that glucose tolerance may be the greatest in the follicular phase; however, further well-conducted studies are needed to support this assumption.

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“…Previous research shows that both butyrate and propionate inhibit the expression of the pro-inflammatory cytokines IL-6 and TNF-α as well as modulate the differentiation and activation of immune cells by signaling through G protein-coupled receptors 44,45 . Propionate has also been shown to have anti-inflammatory properties by decreasing IL-6 release in colon organ cultures 46 and strengthening tight junction barriers in intestinal epithelial cells, thereby reducing intestinal permeability 47 . COVID-19 has previously demonstrated an association with reduced SCFA-producing bacteria in the gut such as Roseburia 48 , which may result in reduced SCFA production and a loss of their potential health benefits.…”

Section: Introductionmentioning

confidence: 99%

SARS-CoV-2 infection is associated with intestinal permeability, systemic inflammation, and microbial dysbiosis in hospitalized COVID-19 patients

Basting,

Langat,

Broedlow

et al. 2023

Preprint

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Coronavirus disease 2019 (COVID-19) and associated severity has been linked to uncontrolled inflammation and may be associated with changes in the microbiome of mucosal sites including the gastrointestinal tract and oral cavity. These sites play an important role in host-microbe homeostasis and disruption of epithelial barrier integrity during COVID-19 may potentially lead to exacerbated inflammation and immune dysfunction. Outcomes in COVID-19 are highly disparate, ranging from asymptomatic to fatal, and the impact of microbial dysbiosis on disease severity is unclear. Here, we obtained plasma, rectal swabs, oropharyngeal swabs, and nasal swabs from 86 patients hospitalized with COVID-19 and 12 healthy volunteers. We performed 16S rRNA sequencing to characterize the microbial communities in the mucosal swabs and measured circulating cytokines, markers of gut barrier integrity, and fatty acids in the plasma samples. We compared these plasma concentrations and microbiomes between healthy volunteers and the COVID-19 patients who had survived or unfortunately died by the end of study enrollment, and between severe disease and healthy controls, as well as performed a correlation analysis between plasma variables and bacterial abundances. The rectal swabs of COVID-19 patients had reduced abundances of several commensal bacteria includingFaecalibacterium prausnitsii, and an increased abundance of the opportunistic pathogensEggerthella lentaandHungatella hathewayi. Furthermore, the oral pathogenScardovia wiggsiaewas more abundant in the oropharyngeal swabs of COVID-19 patients who died. The abundance of bothH. hathewayiandS. wiggsiaecorrelated with circulating inflammatory markers including IL-6, highlighting the possible role of the microbiome in COVID-19 severity, and providing potential therapeutic targets for managing COVID-19.

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Propionate regulates tight junction barrier by increasing endothelial-cell selective adhesion molecule in human intestinal Caco-2 cells

Cited by 17 publications

References 26 publications

Lead exposure aggravates glucose metabolism disorders through gut microbiota dysbiosis and intestinal barrier damage in high‐fat diet‐fed mice

Lead exposure aggravates glucose metabolism disorders through gut microbiota dysbiosis and intestinal barrier damage in high‐fat diet‐fed mice

Impact of Physiological Fluctuations of Sex Hormones During the Menstrual Cycle on Glucose Metabolism and the Gut Microbiota

SARS-CoV-2 infection is associated with intestinal permeability, systemic inflammation, and microbial dysbiosis in hospitalized COVID-19 patients

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