Propionibacterium acnes resistance to antibiotics in acne patients

Leyden, James J.; McGinley, Kenneth J.; Cavalieri, S J; Webster, Guy F.; Mills, Otto H.; Kligman, Albert M.

doi:10.1016/s0190-9622(83)70005-8

Cited by 209 publications

(152 citation statements)

References 8 publications

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“…10 Combination therapy utilizing agents with complementary mechanisms, such as, topical benzoyl peroxide and oral antibiotics, is frequently used in the management of the disorder. 10,11,12 As a first line systemic treatment in adolescence most authors recommend the use of systemic antibiotics, including tetracycline , doxycycline, minocycline and erythromycin. 13,14 Recently, azithromycin has been added to this list 814 Comparative clinical trials have shown that the tolerability profile of azithromycin is superior to that of erythromycin and doxycycline.…”

Section: Discussionmentioning

confidence: 99%

Oral Azithromycin Pulse Therapy and Daily Topical Benzoyl Peroxide in the Treatment of Acne Vulgaris: An Open Clinical Trial Study

Akter

2018

J. Bangladesh Coll. Phys.

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Introduction: Combination therapy is an effective approach to simultaneously target multiple pathogenic factor of acne. A unique combination of oral azithromycin pulse therapy and daily topical benzoyl peroxide has been developed for treatment of acne.Material & Methods: It was an open, controlled, clinical trial, conducted on 37 out patients with acne vulgaris. Patients were clinically assessed at baseline &at week 0,4, 8 and 12. Evaluation included success rate (subjects clear or excellent improvement, good response), lesion count & percentage change in lesion count from baseline, cutaneous tolerability & adverse events.Results: The combination of oral azithromycin pulse therapy & daily topical benzoyl peroxide was very safe & effective with significant differences in percentage of lesion count change observed as early as 1-4 weeks .Adverse events were more frequent with the combination therapy that occurred early in the study &were transient.Conclusion: This study revealed that combination regimen of azithromycin &benzoyl peroxide (4%) is indeed very much efficacious & safe in the management of acne vulgaris.J Bangladesh Coll Phys Surg 2018; 36(1): 11-15

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Section: Discussionmentioning

confidence: 99%

Oral Azithromycin Pulse Therapy and Daily Topical Benzoyl Peroxide in the Treatment of Acne Vulgaris: An Open Clinical Trial Study

Akter

2018

J. Bangladesh Coll. Phys.

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“…Still there are many non compliant patients for many reasons mainly because they are not ready to use treatment for long time or they are afraid from their side effects. Accordingly researcher are look- ing for single therapy that used over short time in order to induce recovery from active lesions and prevent scarring [7,8].…”

Section: Discussionmentioning

confidence: 99%

“…Although there are many topical and systemic agents that have been used in treatment of acne vulgaris, still many patients don't use these therapies and are considered as poor compliance, other patients have no time to use drugs or they don't like to use them or they have phobia from side effects [3][4][5][6][7][8]. But acne vulgaris is one of the cosmetic major problems among the youth and Treatment of Active Acne Vulgaris by Chemical Peeling Using TCA 35% 33 often needs long term therapy because it might often end with complications like scarring [9][10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Treatment of Active Acne Vulgaris by Chemical Peeling Using TCA 35%

Sharquie¹,

Noaimi²,

Al-Janabi³

2013

JCDSA

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Background: The pathogenesis of acne vulgaris is multifactorial, and therapy can be directed at many of these factors, singly or in combination. There are different modalities of treatment of active acne vulgaris but they are often long lasting which could not be accepted by many patients. Objective: To evaluate the effectiveness, long term efficacy and safety of chemical peeling using 35% TCA solution in the treatment of active acne vulgaris. Patients and Methods: This clinical, interventional, therapeutic study was done at the Department of Dermatology-Baghdad Teaching Hospital during the period from January 2012 to March 2013. Eighteen patients with active acne vulgaris were included in this study, 10 (55.6%) females and 8 (44.4%) males. Their ages ranged from 15 to 35 (21.56 ± 5.501) years. Twelve patients were associated with acne scars. History and dermatological examination were performed for all patients regarding all demographic points related to the disease. Chemical peeling with 35% TCA used one session regarding active acne vulgaris and three sessions in patients with associated scarring. Scoring for active acne vulgaris and acne scar was done for each case before and after peeling to evaluate the severity of acne lesions and scarring. All patients were with Fitzpatrick's skin types III and IV. Patients were followed up every two weeks for 12 weeks after starting therapy and every 4 weeks for 12 weeks after stopping the treatment to watch improvement, side effects and relapse. Results: Scoring for active acne vulgaris including papules and pustules showed highly statistically significant reduction after 2 weeks of therapy (p < 0.0001), while in the acne scar scoring reduction ranged from 26% to 50% in 2 patients and 50% to 75% in 2 patients while more than 75% in 8 patients were with statistically significant reduction (p = 0.000002). All patients had full satisfaction with the results of operation. Post inflammatory hyperpigmentation was observed in two patients few weeks after peeling but follow-up showed complete clearance of pigmentation with lightening and tightening of skin. No relapse of active lesion was recorded after twelve weeks follow-up. Conclusions: Chemical peeling by TCA 35% is a cost-effective mode of therapy for active acne vulgaris and acne scar with low down time in patients with dark complexion.

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“…Antibiotic resistance of P. acnes varies between countries and may be difficult to predict. For example, the highest resistance to clindamycin and erythromycin is found in Spain and to tetracycline -in the UK [35]. The relationship between antibiotic resistance and results of acne treatment is probably more complex than in other bacteria-caused diseases.…”

Section: Prevention Of Antibiotic Resistance With Combination Drugsmentioning

confidence: 99%

Role of topical combination drug containing clindamycin and benzoyl peroxide 279 in the treatment of common acne

Pastuszka¹,

Kaszuba²

2012

pdia

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Propionibacterium acnes resistance to antibiotics in acne patients

Cited by 209 publications

References 8 publications

Oral Azithromycin Pulse Therapy and Daily Topical Benzoyl Peroxide in the Treatment of Acne Vulgaris: An Open Clinical Trial Study

Oral Azithromycin Pulse Therapy and Daily Topical Benzoyl Peroxide in the Treatment of Acne Vulgaris: An Open Clinical Trial Study

Treatment of Active Acne Vulgaris by Chemical Peeling Using TCA 35%

Role of topical combination drug containing clindamycin and benzoyl peroxide 279 in the treatment of common acne

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