Propofol: A review of its non-anaesthetic effects

Vasileiou, Ioanna; Xanthos, Theodoros; Koudouna, Eleni; Περρέα, Δέσποινα; Klonaris, Chris; Katsargyris, Αthanasios; Papadimitriou, L.

doi:10.1016/j.ejphar.2009.01.007

Cited by 237 publications

(198 citation statements)

References 114 publications

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“…Propofol also has anti-inflammatory and anti-oxidant properties which may contribute to analgesia. Besides, propofol can selectively inhibit hyperpolarisation-activated cyclic nucleotide-regulated 1 (HCN1) channels, by which it provides an anti-hyperalgesic effect on chronic pain caused by peripheral nerve injury [34,35]. Another putative mechanism through which propofol may exert its analgesic properties is through desensitisation of transient receptor potential cation channel, subfamily A, member 1 (TRPA1), a receptor involved in the sensation of pain, cold and itch [36].…”

Section: Discussionmentioning

confidence: 99%

Effects of intra‐operative maintenance of general anaesthesia with propofol on postoperative pain outcomes – a systematic review and meta‐analysis

et al. 2016

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SummaryPropofol is used both for induction and maintenance of anaesthesia. Recent evidence shows that propofol has analgesic properties. This meta-analysis evaluated differences in postoperative analgesia between general anaesthetic maintenance with intravenous propofol and inhalational anaesthetics. Fourteen trials met inclusion criteria and were included. Our outcomes were pain scores 2 and 24 h after surgery. No significant difference in pain scores was found at 2 h after surgery (Hedge's g (95% CI) À0.120 (À0.415-0.175) (p = 0.425). Propofol was associated with a statistically significant, albeit marginal, reduction in pain scores 24 h after surgery (Hedge's g (95% CI) À0.134 (À0.248 to À0.021) (p = 0.021). Data were insufficient to allow a meaningful analysis regarding 24-h morphine-equivalent consumption. Propofol was associated with reduced postoperative nausea and vomiting (relative risk (95%CI) 0.446 (0.304-0.656) (p < 0.0001). In conclusion, this meta-analysis suggests that propofol improves postoperative analgesia compared with inhalational anaesthesia 24 h after surgery, with a lower incidence of nausea and vomiting.

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Section: Discussionmentioning

confidence: 99%

Effects of intra‐operative maintenance of general anaesthesia with propofol on postoperative pain outcomes – a systematic review and meta‐analysis

et al. 2016

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“…Propofol is an intravenous short-acting anaesthetic agent (Vasileiou et al, 2009) introduced in the 1980's and positively modulates gamma-aminobutyric acid (GABA A ) receptors (Dong and Xu, 2002;Trapani et al, 2000). In a recent study, four anaesthetics; isoflurane, propofol, ketamine, and alpha chloralose, were studied for their effect on cerebral blood perfusion in the striatum.…”

Section: Accepted M Manuscriptmentioning

confidence: 99%

Propofol allows precise quantitative arterial spin labelling functional magnetic resonance imaging in the rat

et al. 2010

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M., Propofol allows precise quantitative arterial spin labelling functional magnetic resonance imaging in the rat, NeuroImage (2010), doi: 10.1016/j.neuroimage. 2010.03.024 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.A C C E P T E D M A N U S C R I P T ACCEPTED MANUSCRIPT

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“…As an intravenous short-acting anesthetic agent, propofol has been widely used in induction and maintenance of anesthesia for decades (Vasileiou et al, 2009). Despite the prevalence of its use, the fundamental question of what the functional target of propofol in the human brain is remains unanswered (Urban, 2002;Urban et al, 2006).…”

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confidence: 99%

The Action Sites of Propofol in the Normal Human Brain Revealed by Functional Magnetic Resonance Imaging

Zhang¹,

Wang²,

Zhao³

et al. 2010

The Anatomical Record

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Propofol has been used for many years but its functional target in the intact brain remains unclear. In the present study, we used functional magnetic resonance imaging to demonstrate blood oxygen level dependence signal changes in the normal human brain during propofol anesthesia and explored the possible action targets of propofol. Ten healthy subjects were enrolled in two experimental sessions. In session 1, the Observer's Assessment of Alertness/Sedation Scale was performed to evaluate asleep to awake/alert status. In session 2, images with blood oxygen level dependence contrast were obtained with echo-planar imaging on a 1.5-T Philips Gyroscan Magnetic Resonance System and analyzed. In both sessions, subjects were intravenously administered with saline (for 3 min) and then propofol (for 1.5 min) and saline again (for 10.5 min) with a constant speed infusion pump. Observer's Assessment of Alertness/Sedation Scale scoring showed that the subjects experienced conscious-sedative-unconscious-analepsia, which correlated well with the signal decreases in the anesthesia states. Propofol induced significant signal decreases in hypothalamus (18.2% AE 3.6%), frontal lobe (68.5% AE 11.2%), and temporal lobe (34.7% AE 6.1%). Additionally, the signals at these three sites were fulminant and changed synchronously. While in the thalamus, the signal decrease was observed in 5 of 10 of the subjects and the magnitude of decrease was 3.9% AE 1.6%. These results suggest that there is most significant inhibition in hypothalamus, frontal lobe, and temporal in propofol anesthesia and moderate inhibition in thalamus. These brain regions might be the targets of propofol anesthesia in human brain. Anat Rec, 293:1985Rec, 293: -1990

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Propofol: A review of its non-anaesthetic effects

Cited by 237 publications

References 114 publications

Effects of intra‐operative maintenance of general anaesthesia with propofol on postoperative pain outcomes – a systematic review and meta‐analysis

Effects of intra‐operative maintenance of general anaesthesia with propofol on postoperative pain outcomes – a systematic review and meta‐analysis

Propofol allows precise quantitative arterial spin labelling functional magnetic resonance imaging in the rat

The Action Sites of Propofol in the Normal Human Brain Revealed by Functional Magnetic Resonance Imaging

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