Propofol anaesthesia for surgery in late gestation pony mares

Taylor, Polly; White, Kate; Fowden, Abigail L.; Giussani, Dino A.; Bloomfield, M; Sear, J.W.

doi:10.1046/j.1467-2987.2001.00044.x

Cited by 19 publications

(34 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…infusion of propofol (0.13-0.20 mg kg Ϫ1 min Ϫ1 ; Rapinovet; SheringPlough, Welwyn Garden City, UK) as described previously [11]. After induction of anesthesia, the mare was placed in right lateral recumbency, and the uterus was exposed through a midline abdominal incision.…”

Section: Operative Proceduresmentioning

confidence: 99%

Ontogeny of Uteroplacental Progestagen Production in Pregnant Mares During the Second Half of Gestation1

Ousey

Forhead

Rossdale

et al. 2003

Biology of Reproduction

View full text Add to dashboard Cite

In pregnant mares during late gestation, little, if any, progesterone (P 4 ) is found in the maternal circulation. Hence, quiescence of the equine uterus is believed to be maintained by metabolites of pregnenolone and P 4 known as progestagens, which are produced by the uteroplacental tissues. However, little is known about the ontogeny, distribution, or actual rates of uteroplacental progestagen production in pregnant mares and their fetuses during the second half of pregnancy. Therefore, the present study measured the rates of uteroplacental uptake and output of eight specific progestagens in chronically catheterized, pregnant pony mares from 180 days to term. No significant uteroplacental uptake of any of the eight individual progestagens was observed from the uterine circulation. In contrast, significant uteroplacental uptake was observed for five of the eight individual progestagens from the umbilical circulation, and the uptakes increased toward term. The major uteroplacental progestagen outputs were 5␣-pregnane-3,20-dione (5␣DHP) and 20␣-hydroxy-5␣-pregnan-3-one (20␣5P). These were released into both the umbilical and uterine circulations at rates that increased toward term. The majority of the total uteroplacental 20␣5P output was distributed into the uterine circulation at all gestational ages studied. In contrast, distribution of the total uteroplacental 5␣DHP output switched from preferential delivery into the uterine circulation before 220 days of gestation to release predominantly into the umbilical circulation after 260 days. These findings demonstrate that uteroplacental progestagen production changes during the second half of gestation, which may have important implications for the maintenance of pregnancy and the onset of labor in the mare. placenta, pregnancy, progesterone, steroid hormones

show abstract

Section: Operative Proceduresmentioning

confidence: 99%

Ontogeny of Uteroplacental Progestagen Production in Pregnant Mares During the Second Half of Gestation1

Ousey

Forhead

Rossdale

et al. 2003

Biology of Reproduction

View full text Add to dashboard Cite

show abstract

“…Recently, use of propofol as an induction or maintenance agent in horses has been reported [53][54][55][56][57][58][59]. Propofol is an intravenous anesthetic drug used widely in people and small animals for induction and maintenance of anesthesia, with a major advantage being rapid metabolism and quicker return to coordinated activity.…”

Section: Anesthetic Induction and Maintenancementioning

confidence: 99%

“…Propofol dosages are listed in Table 1. Several TIVA protocols have been reported to provide adequate analgesia with preservation of cardiovascular function and arterial oxygenation [47,52,[58][59][60][61]. Two studies demonstrated that the TIVA protocol used provided superior arterial blood pressure values compared with halothane [62,63].…”

Section: Anesthetic Induction and Maintenancementioning

confidence: 99%

“…A retrospective study reporting delivery of eight live foals by elective equine cesarean section used guaifenesin or guaifenesin and ketamine with supplemental oxygen until foals were delivered [124]. Two TIVA protocols in pregnant pony mares, one using guaifenesin, detomidine, and ketamine and the other using propofol after acepromazine-butorphanol-detomidine-ketamine induction, resulted in stable cardiovascular function with no fetal losses [52,59]. The following points should be considered for anesthesia of pregnant mares:…”

Section: Pregnancymentioning

confidence: 99%

See 1 more Smart Citation

Anesthesia of the critically ill equine patient

Cornick-Seahorn¹

2004

Veterinary Clinics of North America: Equine Practice

View full text Add to dashboard Cite

“…Between 165 and 300 days of gestation, the mares were pre-medicated and, then, anaesthetised with a bolus dose of ketamine (2 mg/kg bolus) followed by a continuous intravenous infusion of propofol (0·13-0·20 mg/kg per min Rapinovet; Shering-Plough, Harefield, UK) as described previously (Taylor et al 2001). After induction of anaesthesia, the mare was placed in right lateral recumbency and the uterus was exposed through a midline abdominal incision.…”

Section: Operative Proceduresmentioning

confidence: 99%

Maturation of pancreatic β-cell function in the fetal horse during late gestation

Fowden

Gardner²,

Ousey³

et al. 2005

Journal of Endocrinology

View full text Add to dashboard Cite

At birth, the endocrine pancreas becomes more directly involved in the control of glycaemia than in utero. However, compared with other tissues, relatively little is known about the maturational changes that occur in the fetal endocrine pancreas in preparation for extrauterine life. This study examined the pancreatic -cell response to exogenous administration of glucose and arginine in fetal horses with respect to their gestational age and concentration of cortisol, the hormone responsible for prepartum maturation of other fetal tissues. Glucose administration had no effect on fetal insulin secretion between 175 and 230 days of gestation but evoked a rapid insulin response in fetuses closer to term (290-327 days). In late gestation, the -cell response was more rapid and greater in magnitude in fetuses with basal cortisol levels higher than 15 ng/ml than in those with lower cortisol values at the time of glucose administration. The fetal -cell response to arginine was unaffected by the rise in fetal plasma cortisol towards term. These findings show that there are maturational changes in pancreatic -cell function in fetal horses as cortisol levels rise close to term. Primarily, these prepartum maturational changes were in the mechanisms of glucose-stimulated insulin secretion, which would enable the cells to regulate glycaemia at the higher glucose levels observed postnatally.

show abstract

Propofol anaesthesia for surgery in late gestation pony mares

Cited by 19 publications

References 29 publications

Ontogeny of Uteroplacental Progestagen Production in Pregnant Mares During the Second Half of Gestation1

Ontogeny of Uteroplacental Progestagen Production in Pregnant Mares During the Second Half of Gestation1

Anesthesia of the critically ill equine patient

Maturation of pancreatic β-cell function in the fetal horse during late gestation

Contact Info

Product

Resources

About