Propofol-based sedation regimen for infants and children undergoing ambulatory magnetic resonance imaging

Abstract

This sedation regimen provides the shortest induction time so far described, a rare demand for additional sedation, a low incidence of respiratory events, and a rapid recovery.

Evaluation of 865 children who underwent magnetic resonance imaging under propofol-midazolam sedation

“…Propofol has rapid induction, better recovery and quick catabolism without redistribution. It is usually the first-line drug for outpatient anesthesia procedures which does not cause nausea and vomiting 3 . However, the disadvantages are respiratory and hemodynamic depression, shorter duration of effect, dose-dependent effect, and absence of any antagonist drug 8 .…”

“…However, number of patients were not sufficient to make a decision, and meanwhile other drugs added in this combination hindered obtaining a clear result concerning the risks and effectiveness of propofolmidazolam treatment 3,9 . As a result, debates are going on.…”

“…Oral, rectal or intramuscular narcotics and barbiturates are occasionally inadequate to ensure a proper sedation without movement for children especially with mental retardation [1][2][3][4] . In addition, MRI is a noninvasive but a noisy study, and patient must be completely immobile to obtain a good image [1][2][3][4] . Because of these reasons, sedation or general anesthesia is needed [1][2][3][4] .…”

“…In addition, MRI is a noninvasive but a noisy study, and patient must be completely immobile to obtain a good image [1][2][3][4] . Because of these reasons, sedation or general anesthesia is needed [1][2][3][4] . At this stage, the selected anest- hetic agent must be a fast-acting sedative and recovery must be in a short time 3,5,6 .…”

“…Because of these reasons, sedation or general anesthesia is needed [1][2][3][4] . At this stage, the selected anest- hetic agent must be a fast-acting sedative and recovery must be in a short time 3,5,6 . Besides, the selected drug must have no adverse effects like vertigo, nausea and vomiting that may cause prolonged hospitalization.…”