Propofol during Cardiopulmonary Bypass in a Patient Susceptible to Malignant Hyperpyrexia

Abstract

In spite of improvements in surgical technique and myocardial preservation, low cardiac output occasionally presents a problem following cardiopulmonary bypass (CPB) for coronary artery surgery. Low cardiac output in combination with ischaemic heart disease is associated with a poor

Successful management of hypothermic cardiopulmonary bypass in a malignant hyperthermia susceptible patient

“…[ 7 ] Out of the 24 cases in the review, 14 patients experienced an MH event, whereas 10 did not. [ 8 9 10 11 12 13 14 15 16 17 ] Of the 14 patients who experienced MH episodes, 10 were attributed to the use of volatile agents. [ 18 19 20 21 22 23 24 25 ] The triggering agent for the other 4 patients remained unknown, however, no known triggering anesthetic agents were used.…”

“…None of these agents have been shown to cause adverse toxic reactions in MH-susceptible patients. [ 8 ] It is noteworthy to mention that the incidence of MH crisis is thought to be less in individuals of black African descent. [ 35 36 37 38 39 ] A case report of a 28-year-old African American male with prior uneventful anesthetic treatment with isoflurane reported an MH event in a subsequent maxillofacial procedure utilizing desflurane.…”