Propofol for procedural sedation/anesthesia in neonates

Shah, Prakeshkumar S; Shah, Vibhuti

doi:10.1002/14651858.cd007248

Cited by 3 publications

(4 citation statements)

References 19 publications

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“…However, levels reached baseline preinduction levels within 24 h. At no point of time after 90 min did hypertriglyceridemia occur in any of the patients (defined as 150% of upper normal limit, i.e., 270 mg·dl −1 ) nor were there any relevant clinical manifestations. In agreement with us, several studies recorded a significant rise in TG levels, although not reaching the level of hypertriglyceridemia.…”

Section: Discussionsupporting

confidence: 90%

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Effect of short‐term propofol administration on pancreatic enzymes and lipid biochemistry in children between 1 month and 36 months

Chauhan

Garg

Bharadwaj

2012

Pediatric Anesthesia

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Section: Discussionsupporting

confidence: 90%

“…Propofol has come to be used extensively for induction and maintenance of anesthesia in the pediatric age group, the minimum age group being lowered further with passing time. Its use is now being considered in neonates.…”

Section: Discussionmentioning

confidence: 99%

Effect of short‐term propofol administration on pancreatic enzymes and lipid biochemistry in children between 1 month and 36 months

Chauhan

Garg

Bharadwaj

2012

Pediatric Anesthesia

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“…In the central nervous system, propofol induces a dose-dependent suppression of awareness. Prolonged sedation with propofol may cause neurologic sequelae in children [39], [71], and [12] and short-term sedation may cause convulsions [24], [58] and [74]. The mechanisms of propofol action and potential toxicity have been studied in vitro; however, results have been conflicting (i.e., clinical levels may be without effect in some systems but not others, and different endpoints used among studies do not permit direct comparisons) [65].…”

Section: Model Cell Types and Neurotoxicantsmentioning

confidence: 99%

Image analysis of Ca2+ signals as a basis for neurotoxicity assays: Promises and challenges

Barhoumi¹,

Qian²,

Burghardt³

et al. 2010

Neurotoxicology and Teratology

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Free intracellular calcium ([Ca 2+ ] i ) controls a wide range of cellular functions such as contraction, neurotransmitter and hormone release, metabolism, cell division and differentiation. Cytosolic Ca 2+ levels are abnormal in cells exposed to toxicants and understanding how these levels become altered may improve our ability to design high-throughput methods for the sensitive detection of cellular responses to a toxic exposure. Because Ca 2+ is involved in multiple aspects of cellular function, its role in signaling is complex. It is therefore necessary to identify the individual pathways targeted during toxicant exposure in order to use them as a tool for predictive measurements of toxicity and as targets for prevention or reversal of injury. This review illustrates several methods available for analysis of Ca 2+ responses in vitro and their applicability for understanding mechanisms of toxicity at the molecular and cellular levels. The review will also consider the usefulness of Ca 2+ imaging for predicting a unique signature for classes of toxicants. Towards this end, two methodological approaches for assessment of Ca 2+ responses to toxicants are examined: steady state measurements and complex spatial and/or temporal measurements. Each of the methods described and appropriately used results in reliable and reproducible measurements which may be applied in a high-throughput fashion to individualize in vitro assessment of cellular responses caused by toxicants.

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“…The main four types release either chlorhexidine/sulphadiazine, antibiotic substances, heparin, or silver ions. Although evidence of their effect on reducing catheter colonization, CRBSI, or both is good, results to their effect on the different levels of CVC‐borne infection and results of head‐to‐head comparisons of antimicrobial CVCs with different coatings lack consistency …”

Section: Introductionmentioning

confidence: 99%

Quantitative Comparison of the Antimicrobial Efficiency of Leaching versus Nonleaching Polymer Materials

Bruenke¹,

Roschke²,

Agarwal

et al. 2016

Macromolecular Bioscience

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New antimicrobial materials will be more and more in the focus for hygienic and clinical disease control. Antimicrobial materials have to be distinguished in leaching and nonleaching materials. For many applications of antimicrobial materials on implants the use of nonleaching materials is essential. Therefore, the antimicrobial efficiency of leaching and nonleaching polymers has been investigated quantitatively in vitro in direct comparison on a highly relevant implant of central venous catheters (CVCs) using a well‐established called Certika test. This test is especially designed to test antimicrobial properties of leachable and nonleachable materials. This contribution demonstrates that newly developed nonleaching antimicrobial CVCs are equivalent to conventional leaching CVC systems in their antimicrobial performance against gram‐positive and gram‐negative bacteria, as well as Candida species. The use of new nonleaching antimicrobial polymers as shown here for CVCs represents a different mode of action with the aim to prevent infections also with antibiotic‐resistant strains and reduced side effects.

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Propofol for procedural sedation/anesthesia in neonates

Cited by 3 publications

References 19 publications

Effect of short‐term propofol administration on pancreatic enzymes and lipid biochemistry in children between 1 month and 36 months

Effect of short‐term propofol administration on pancreatic enzymes and lipid biochemistry in children between 1 month and 36 months

Image analysis of Ca2+ signals as a basis for neurotoxicity assays: Promises and challenges

Quantitative Comparison of the Antimicrobial Efficiency of Leaching versus Nonleaching Polymer Materials

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