Propofol has delayed myocardial protective effects after a regional ischemia/reperfusion injury in an in vivo rat heart model

Abstract

BackgroundIt is well known that propofol protects myocardium against myocardial ischemia/reperfusion injury in the rat heart model. The aim of this study was to investigate whether propofol provides a protective effect against a regional myocardial ischemia/reperfusion injury in an in vivo rat heart model after 48 h of reperfusion.MethodsRats were subjected to 25 min of left coronary artery occlusion followed by 48 h of reperfusion. The sham group received profopol without ischemic injury. The control group received normal saline with ischemia/reperfusion injury. The propofol group received profopol with ischemia/reperfusion injury. The intralipid group received intralipid with ischemia/reperfusion injury. A microcatheter was advanced into the left ventricle and the hemodynamic function was evaluated. The infarct size was determined by triphenyltetrazolium staining. The serum level of cardiac troponin-I (cTn-I) was determined by ELISA (enzyme-linked immunosorbent assay).ResultsPropofol demonstrated protective effects on hemodynamic function and infarct size reduction. In the propofol group, the +dP/dtmax (P = 0.002) was significantly improved compared to the control group. The infarct size was 49.8% of the area at risk in the control group, and was reduced markedly by administration of propofol to 32.6% in the propofol group (P = 0.014). The ischemia/reperfusion-induced serum level of cTn-I was reduced by propofol infusion during the peri-ischemic period (P = 0.0001).ConclusionsPropofol, which infused at clinically relevant concentration during the peri-ischemic period, has delayed myocardial protective effect after regional myocardial ischemia/reperfusion injury in an in vivo rat heart model after 48 h of reperfusion.

Propofol exhibits a tumor‑suppressive effect and regulates cell viability, migration and invasion in bladder carcinoma by targeting the microRNA‑10b/HOXD10 signaling pathway

“…Numerous anesthetics are used for cancer surgery, such as propofol, remifentanil and sevoflurane (26,27); however, their effects on the potential behaviors of cancer remain unknown. Propofol is an anesthetic agent that exerts numerous anesthetic, neuroprotective and myocardial-protective effects (18,28,29). Previous studies have demonstrated an association between propofol use and antitumor effects (20,21).…”

Application of peripheral-blood-derived endothelial progenitor cell for treating ischemia-reperfusion injury and infarction: a preclinical study in rat models

“…The catheter was advanced into the left ventricle (LV) to measure the heart rate (HR), left ventricular systolic pressure (LVSP), left ventricular end diastolic pressure (LVEDP), the increase in the peak rate of intraventricular pressure increase (+dP/dtmax), and the decrease in the peak rate of intraventricular pressure (−dP/dtmax) [20]. …”

Ethyl Pyruvate Has Anti-Inflammatory and Delayed Myocardial Protective Effects after Regional Ischemia/Reperfusion Injury

“…All animals were maintained in accordance with the Guidelines for the Care and Use of Laboratory Animals published by the US National Institutes of Health in 1996. Animal preparation and surgery were done according to previous report 13. Animals received general anesthesia with an intramuscular injection of 80 mg/kg ketamine (ketamine HCl®, Huons, Seoul, Korea) and 8 mg/kg zylazine (Rompun®, Bayer Korea, Seoul, Korea).…”