Propofol in the Management of Myoclonus Syndrome Induced by Chloralose Poisoning

Comparison of the influence of low dose etomidate and propofol as priming dose on the incidence of etomidate induced myoclonus: a randomised, double-blind clinical trial

“…The significant reduction of myoclonus occurs with drugs (benzodiazepines or opioids) and with pre-treatment with low dose etomidate, and propofol is known to inhibit the subcortical neuronal activity, or through enhancement of γ aminobutyric acid type A receptor. 4 , 9 , 16 , 17 In this study by Doenicke et al on EEG with etomidate, it was hypothesized that inhibitory circuits are depressed earlier and with low dose compared to excitatory circuits. This was the basis for using a low dose of etomidate as priming dose before induction with etomidate for reduction of myoclonus.…”