Propofol Infusion Therapy

Grandhi, Ravi K.; Abd‐Elsayed, Alaa

doi:10.1007/978-3-030-17478-1_3

Cited by 1 publication

(1 citation statement)

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“…Remarkably, some characteristics of propofol, including the rapid onset of hypnosis, titratability, short duration of action, rapid elimination, and minimal effects on evoked potentials make it ideal for general anesthesia, monitored anesthesia care, and total intravenous (IV) anesthesia. In addition, propofol causes the potentiation of GABA receptors and the antagonism of NMDA receptors (7). The chemical structure of propofol contains a phenolic hydroxyl group which is similar to that of α-tocopherol (vitamin E), which is a natural antioxidant.…”

Section: Introductionmentioning

confidence: 99%

Pulmonary Protective Effects of Propofol on Cisplatin-Induced Oxidative Damage in Male Rats

Makhdoomi

Oftade

Khodabandehlou

et al. 2020

Avicenna J Pharm Res

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Background: The present study was performed to investigate the protective effects of propofol against cisplatin-induced pulmonary toxicity in rats. Methods: A total of 20 male Wistar rats weighing 180-250 g were divided into four groups of control, the cisplatin-intoxicated group intraperitoneally (IP) injected with cisplatin (7 mg/kg/d for a week), the propofol group (10 mg/kg/d, IP), and the protected group receiving propofol (10 mg/kg/d, IP) poisoned by cisplatin. Then, the biomarkers of total antioxidant capacity (TAC), catalase (CAT) activity, and lipid peroxidation (LPO) were measured in homogeneous lung tissues. Results: The data revealed the evidence of oxidative stress in the lung tissue of cisplatin-intoxicated rats as indicated by an increase in the level of LPO compared with propofol and protected groups (P<0.05). Moreover, TAC decreased in the cisplatin group while it increased in the propofol group compared to cisplatin and protected groups (P<0.05). No significant difference was observed between the groups regarding CAT (P>0.05). Protection with propofol ameliorated the oxidative stress induced by cisplatin in the lung tissue because of the reduction of LPO. Conclusion: According to these results, it seems that propofol provides a remarkable protection against cisplatin-induced oxidative pulmonary damage mediated by its antioxidant properties.

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Section: Introductionmentioning

confidence: 99%