Propofol post-conditioning after temporary clipping reverses oxidative stress in aneurysm surgery

Guo, Deyin; Li, Yanli; Wang, Haiyun; Hua, Wei; Tang, Qingkai; Miao, Lu-min; Wang, Guolin

doi:10.1080/00207454.2018.1483920

Cited by 19 publications

(12 citation statements)

References 37 publications

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“…In another study, 19 In our study, when we look at the evaluation of dynamic TDH within the groups and the correlation values with other markers, it was shown that propofol caused less reduction in native thiol, total thiol and disulfide values compared with desflurane in elective vertebral surgery and had a more positive contribution to oxidative stress. The findings of our study, as reported in the literature, 17,19,20 support that propofol has antioxidant properties. We can say that propofol is a better agent than desflurane in elective vertebral surgery due to its neuroprotective effects and antioxidant properties.…”

Section: Discussionmentioning

confidence: 54%

Stress response in vertebra surgery by total intravenous and inhalation anaesthesia

et al. 2021

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Oxidative stress can be created by an imbalance between the production of oxygen-containing free radicals known as reactive oxygen species (ROS) and their elimination. Although ROS are necessary for normal metabolism, such as killing external harmful factors and providing cellular signalling in cells, ROS overproduction can cause cellular dysfunction. 1 Free radicals are compounds containing unpaired electrons in one of their atomic or molecular orbits. They are reactive and short-lived. Free radicals can be produced as a continuation of a normal metabolism or by many reactions necessary for energy production in the cell. 2 ROS are highly reactive molecules and are produced as a result of normal metabolism in cell organelles, especially mitochondria, or due to causes such as ischaemia/reperfusion, aging, radiation, high oxygen pressure, inflammation and exposure to chemical agents. 3 Thiols are organic compounds that contain a sulfhydryl group (-SH) attached to a carbon atom and play an important role in defense against oxidative stress. The main thiols found in plasma are low molecular weight thiols including albumin, cysteine, cysteinylglycine, glutathione (GSH), homocysteine and γ-glutamyl cysteine. 4 Thiols are the most important reducing molecules in the body, oxidise ROS formed in the organism and reduce excess electrons, and disulfide bonds are formed. The disulfide bonds formed are reversible. It can turn into thiols depending on the antioxidant/oxidant balance of the organism. In this way, a dynamic thiol/disulfide homoeostasis (TDH) is preserved. 5

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Section: Discussionmentioning

confidence: 54%

Stress response in vertebra surgery by total intravenous and inhalation anaesthesia

et al. 2021

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“…A prospective, randomized trial by Guo et al [ 65 ] evaluated in 60 patients undergoing aneurysm clipping the role of propofol postconditioning on oxidative stress and postoperative cognitive function. The patients were randomized into a propofol postconditioning group or a sevoflurane group.…”

Section: Intravenous Anestheticsmentioning

confidence: 99%

“…Postoperatively, micronuclei as well as nucleoplasmic bridges were seen more frequently in the sevoflurane group. Finally, the propofol postconditioning group had markedly higher scores on cognitive function tests compared with the sevoflurane group after the surgery [ 65 ].…”

Section: Intravenous Anestheticsmentioning

confidence: 99%

Anesthesia‐Induced Oxidative Stress: Are There Differences between Intravenous and Inhaled Anesthetics?

Senoner

Velik‐Salchner

Luckner

et al. 2021

Oxidative Medicine and Cellular Longevity

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Agents used for the induction of anesthesia have been shown to either promote or mitigate oxidative stress. A fine balance between the presence of reactive oxygen species (ROS) and antioxidants is crucial for the proper normal functioning of the cell. A basal concentration of ROS is essential for the manifestation of cellular functions, whereas disproportionate levels of ROS cause damage to cellular macromolecules such as DNA, lipids, and proteins, eventually leading to necrosis and apoptosis. Increased ROS has been linked with numerous illnesses, such as cardiovascular, immune system, liver, and kidney, and has been shown to promote cancer and accelerate aging. Knowledge of the various pharmacologic agents that increase or reduce oxidative stress may promote a safer way of inducing anesthesia. Furthermore, surgery itself leads to increased ROS production and ischemia/reperfusion injury. Indeed, increased perioperative oxidative stress has been correlated with increased postoperative complications and prolonged recovery. Anesthesiologists care for patients during the whole spectrum of perioperative care and thus are in a unique position to deliver countermeasures to oxidative stress. Using preferentially an induction agent which reduces oxidative stress might lead to better clinical outcomes and fewer postoperative complications. Propofol has been shown in several studies to reduce oxidative stress, which reduces postoperative complications and leads to a faster recovery, and thus might represent the preferred induction agent in the right clinical setting.

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“…In addition, cognitive function was better in the propofol treated group when measured by Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA) scores up to 7 days after surgery. The authors proposed that propofol post-conditioning may protect against oxidative stress injury by enhancing antioxidation and decreasing free radical injury [ 20 ].…”

Section: Anesthetics/adjuvants In Ebi After Sahmentioning

confidence: 99%

Role of Anesthetics and Their Adjuvants in Neurovascular Protection in Secondary Brain Injury after Aneurysmal Subarachnoid Hemorrhage

Athiraman

Zipfel

2021

IJMS

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Aneurysmal rupture accounts for the majority of subarachnoid hemorrhage and is responsible for most cerebrovascular deaths with high mortality and morbidity. Initial hemorrhage severity and secondary brain injury due to early brain injury and delayed cerebral ischemia are the major determinants of outcomes after aneurysmal subarachnoid hemorrhage. Several therapies have been explored to prevent these secondary brain injury processes after aneurysmal subarachnoid hemorrhage with limited clinical success. Experimental and clinical studies have shown a neuroprotective role of certain anesthetics in cerebrovascular disorders including aneurysmal subarachnoid hemorrhage. The vast majority of aneurysmal subarachnoid hemorrhage patients require general anesthesia for surgical or endovascular repair of their aneurysm. Given the potential impact certain anesthetics have on secondary brain injury after SAH, appropriate selection of anesthetics may prove impactful on overall outcome of these patients. This narrative review focuses on the available evidence of anesthetics and their adjuvants in neurovascular protection in aneurysmal subarachnoid hemorrhage and discusses current impact on clinical care and future investigative directions.

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Propofol post-conditioning after temporary clipping reverses oxidative stress in aneurysm surgery

Cited by 19 publications

References 37 publications

Stress response in vertebra surgery by total intravenous and inhalation anaesthesia

Stress response in vertebra surgery by total intravenous and inhalation anaesthesia

Anesthesia‐Induced Oxidative Stress: Are There Differences between Intravenous and Inhaled Anesthetics?

Role of Anesthetics and Their Adjuvants in Neurovascular Protection in Secondary Brain Injury after Aneurysmal Subarachnoid Hemorrhage

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