Propofol relieves post-extubation laryngospasm in obstetric anesthesia

Fodale, Vincenzo; Praticò, C; Leto, G.; Caminiti, Vincenzo; Mazzeo, Anna Teresa; Lucanto, T

doi:10.1016/j.ijoa.2004.02.001

Cited by 10 publications

(7 citation statements)

References 12 publications

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“…Propofol can be used at doses 0.25–0.8 mg·kg −1 because of its rapid and predictable action, but if there is no i.v. line inhalational anesthesia can be used (29,56–59). If this technique fails and oxyhemoglobin desaturation ensues (SpO 2 < 85%) suxamethonium can be given at doses of 0.1–3 mg·kg −1 followed by mask ventilation and, or tracheal intubation (60–62).…”

Section: Treatmentmentioning

confidence: 99%

“…The question of whether to use propofol or suxamethonium is a matter of timing. Propofol should be used prior to suxamethonium because it is successful in treating laryngospasm in 76.9% of cases (29,58,59). In addition, propofol offers many advantages over suxamethonium.…”

Section: Treatmentmentioning

confidence: 99%

“…Second, avoiding suxamethonium will eliminate the possibility of prolonged paralysis in patients with pseudocholinesterase deficiency. Finally, propofol can be used when suxamethonium is contraindicated, such as in patients with muscular dystrophy, recent burns, spinal cord transection or hyperkalemia (58,61). Suxamethonium still has a crucial role when propofol is unsuccessful (59) and its administration should not be delayed until the patient becomes severely desaturated (SpO 2 < 85%).…”

Section: Treatmentmentioning

confidence: 99%

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Laryngospasm: review of different prevention and treatment modalities

Al-Alami

Ayoub

Baraka

2008

Pediatric Anesthesia

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Section: Treatmentmentioning

confidence: 99%

Section: Treatmentmentioning

confidence: 99%

Section: Treatmentmentioning

confidence: 99%

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Laryngospasm: review of different prevention and treatment modalities

Al-Alami

Ayoub

Baraka

2008

Pediatric Anesthesia

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“…[ 26 ] At subhypnotic doses, its preventive effect on laryngospasm has been reported. [ 19 27 28 ] Afshan et al . [ 27 ] used a small dose of propofol (0.8 mg/kg) for the management of laryngospasm on removal of the laryngeal mask airway and reported it as a useful drug with the success rate of 77%.…”

Section: Discussionmentioning

confidence: 99%

The effects of propofol, ketamine and combination of them in prevention of coughing and laryngospasm in patients awakening from general anesthesia: A randomized, placebo-controlled, double blind clinical trial

2016

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Background:Coughing and laryngospasm are undesirable outcomes occurring during emergence from general anesthesia. We compared the effect of small doses of propofol, ketamine and a combination of them on the occurrence and severity of coughing and laryngospasm in patients awakening from general anesthesia.Materials and Methods:160 patients who were scheduled to undergo operations under general anesthesia were randomly assigned to one of the following groups, 40 in each group: propofol group (0.25 mg/kg intravenous (IV) propofol), ketamine group (0.25 mg/kg IV ketamine), combination group (0.25 mg/kg IV propofol, and 0.25 mg/kg IV ketamine) and control (0.1 ml/kg IV saline). Drugs were administered before extubation at previously defined time. Presence and severity of coughing and laryngospasm were recorded within twominutes after extubation.Results:The presence of coughing in the combination group (27.5%) was less than that in other groups; also it was less frequent in the propofol group (57.5%) than the control (82.5%) (all P < 0.05). But the incidence did not differ between the propofol and the ketamine (70%) group; nor did it differ between the ketamine and control groups (P = 0.356 and P = 0.121, respectively). The cases with severe coughing (grade 3) in the combination group (none) were significantly less than in the propofol (four) and the control groups (seven) (P = 0.040 and P = 0.006 respectively). There was no significant difference between the groups in frequency of laryngospasm.Conclusion:Administration of propofol or combination of propofol and ketamine decreases the incidence of post extubation coughing. This combination can also decrease severe cases.

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“…can treat laryngospasm in 76.9% of cases. However, propofol is not studied in children less than 3-year-old [57,[111][112][113]. Succinylcholine is still considered the gold standard for treatment of laryngospasm.…”

Section: Treatment Using Drugsmentioning

confidence: 99%