Propofol suppresses cell proliferation in gastric cancer cells through NRF2‐mediated polyol pathway

Cao, Yajun; Fan, Lixia; Li, Linkai; Zhou, Jiexian

doi:10.1111/1440-1681.13595

Cited by 8 publications

(3 citation statements)

References 57 publications

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“…However, numerous studies have produced the opposite findings for different cancers. More recently, this dysfunction of metabolic reprogramming was documented on gastric cancer cells; however, in this case, the cell proliferation was suppressed through the Nrf2-mediated polyol pathway [39].…”

Section: Effect On Cancer Treatmentmentioning

confidence: 91%

Personalized Medicine for Classical Anesthesia Drugs and Cancer Progression

Costa

Mourão

Vale

2022

JPM

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In this review, we aim to discuss the use and effect of five different drugs used in the induction of anesthesia in cancer patients. Propofol, fentanyl, rocuronium, sugammadex, and dexamethasone are commonly used to induce anesthesia and prevent pain during surgery. Currently, the mechanisms of these drugs to induce the state of anesthesia are not yet fully understood, despite their use being considered safe. An association between anesthetic agents and cancer progression has been determined; therefore, it is essential to recognize the effects of all agents during cancer treatment and to evaluate whether the treatment provided to the patients could be more precise. We also highlight the use of in silico tools to review drug interaction effects and safety, as well as the efficacy of the treatment used according to different subgroups of patients.

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Section: Effect On Cancer Treatmentmentioning

confidence: 91%

Personalized Medicine for Classical Anesthesia Drugs and Cancer Progression

Costa

Mourão

Vale

2022

JPM

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“…Так, Yajun Cao із співавт. показали, що пропофол пригнічує проліферацію клітин, що може визначити його вибір для седації пацієнтів із раком шлунка [14]. До того ж пропофол може інгібувати інвазію, міграцію, проліферацію епітеліально-мезентеріальних клітин у печінковоклітинній карциномі, сприяючи експресії miР-363 [15], а також пригнічувати проліферацію, міграцію клітин остеосаркоми через вісь FOXO1/TUSC7, регулюючи передачу сигналів AKT/GSK3β [16].…”

Section: особливості реакцій організму дітей з онкологічними захворюв...unclassified

Features of body reactions in children with oncological diseases during intravenous anesthesia with propofol

Snisar¹,

Myronov²

2022

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Background. Surgery is one of the cornerstones of cancer treatment. Recently, total intravenous anesthesia (TIA) has become more popular and practical in oncological surgeries due to several main reasons. However, it is important to assess the adaptive reactions of children who undergo surgical treatment and anesthesia. The objective: to study the compensatory and adaptive mechanisms in response to surgical and anesthetic stress, adequacy of TIA in children with oncological diseases by assessing the level of stress hormones and indicators of heart rate variability. Materials and methods. Twenty-three children with cancer aged 10.68 ± 4.51 years (first group) were examined, and also 27 children aged 9.30 ± 3.85 years (second group) were operated for minor trauma. Surgeries in children of both examined groups were performed under total intravenous anesthesia with propofol. Results. Already at the second stage of observation, 100 % of patients in the first group had a significant decrease in systolic blood pressure. As for trauma patients, only 92.59 % of them had a decrease in the level of systolic pressure on the background of TIA at the second stage, and 77.77 % of patients had it even at the third stage. Analyzing the parameters of heart rate variability, we saw that 30.43 % of cancer patients already at the second stage of the research had an increase in the level in the high frequency range. As for the power of the low-frequency spectrum, its decrease was noted in half of the patients. All examined people had elevated cortisol levels. However, children with tumors had a 2.8-fold its increase, trauma patients — a 4.4-fold increase. At the same time, children with cancer had higher initial level of cortisol. Conclusions. Children with oncology and children with trauma have different profiles of stress reactions. Total intravenous anesthesia with propofol improved the outcomes of surgical treatment by suppressing extreme stress reactions. Further research is needed to understand how to optimize the modulation of stress responses and to find precise markers for optimal modulation.

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“…13,14 Complete surgical resection is still the only way to cure gastric cancer, so it is vital to identify the factors that influence the long-term prognosis of patients with gastric cancer after radical surgery during anaesthesia in order to improve the prognosis. Propofol, a widely used short-acting intravenous sedative drug, is gradually gaining attention due to its tumorsuppressive and non-anaesthetic effects, 15 which can reduce the migration and invasion of gastric cancer MGC-803 cells by inhibiting HDAC1 expression and the downstream p38MAPK pathway, 16 and also inhibit gastric cancer cell proliferation and migration by upregulating microRNA-29 cell proliferation and migration through upregulation of microRNA-29. 17 Relevant clinical studies have shown that propofol can inhibit tumor growth and metastatic activity.…”

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confidence: 99%

Effect of Propofol or Etomidate as General Anaesthesia Induction on Gastric Cancer: A Retrospective Cohort Study with 10 Years’ Follow-Up

Lu¹,

Yu²,

Wang³

et al. 2022

CMAR

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The aim is to study the effect of intraoperative application of propofol and etomidate on the long-term prognosis of patients with gastric cancer at the same tumor stage. Methods: A total of 1018 patients who underwent radical gastric cancer surgery at the First Affiliated Hospital of Anhui Medical University from January 2010 to December 2010 were selected and divided into the propofol and etomidate groups according to the different anesthetic induction drugs. Results: Among 244 patients in TNM stage IIIA, survival times were 36.10 and 41.79 for etomidate and propofol, respectively, which were statistically different (p < 0.05). Among the 82 patients in TNM stage IIIC, survival times were 26.57 and 35.20 for etomidate and propofol, respectively, which were statistically different (p < 0.05). Conclusion:In patients undergoing radical gastric cancer surgery, the application of propofol during induction of anaesthesia is more beneficial in improving the postoperative survival time compared to the application of etomidate at a specific TNM stage.

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Propofol suppresses cell proliferation in gastric cancer cells through NRF2‐mediated polyol pathway

Cited by 8 publications

References 57 publications

Personalized Medicine for Classical Anesthesia Drugs and Cancer Progression

Personalized Medicine for Classical Anesthesia Drugs and Cancer Progression

Features of body reactions in children with oncological diseases during intravenous anesthesia with propofol

Effect of Propofol or Etomidate as General Anaesthesia Induction on Gastric Cancer: A Retrospective Cohort Study with 10 Years’ Follow-Up

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