Propofol suppresses the growth and invasion of cervical carcinoma cells by inhibiting MIR155HG

Du, Xin-Tan; Wang, Xiaoyan; Zheng, Ying-He; Liu, Dapeng

doi:10.18632/aging.203697

Cited by 3 publications

(2 citation statements)

References 35 publications

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“…17 Propofol is a widely used intravenous anesthetic, and increasing evidence has shown that at clinically relevant concentrations (10-100 μM), propofol significantly suppresses the malignant biological behaviors of cancer cells. [18][19][20] Du et al 21 demonstrated that 30-100 μM propofol reduced the viability of CaSki and SiHa cells in a dose-and time-dependent manner. However, our study demonstrated that 0-100 μM propofol had no effect on cell viability after treatment for 24 and 48 h and that 30 μM propofol did not affect the malignancy of HeLa and CaSki cells after treatment for 48 h. Mitosis is a necessary pathway for cancer cell proliferation.…”

Section: Discussionmentioning

confidence: 99%

The effect of propofol on chemosensitivity of paclitaxel in cervical cancer cells

et al. 2023

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Section: Discussionmentioning

confidence: 99%

The effect of propofol on chemosensitivity of paclitaxel in cervical cancer cells

et al. 2023

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“…In glioma U87 and U251 cells, RES upregulated NEAT1, MIR155HG, MEG3, and ST7OT1 during induction of apoptosis [ 201 ]. Since NEAT1 and MIR155HG are oncogenic [ 202 , 203 , 204 ] and MEG3 is tumor-suppressing [ 166 ], the effect of RES on MEG3 may be a predominant contributor to apoptosis of these cells. NEAT1 was demonstrated to activate ERK, which is a component molecule in RSTAPs ( Figure 1 ) [ 202 ].…”

Section: Involvements Of Lncrs In Rstapsmentioning

confidence: 99%

Contribution of Non-Coding RNAs to Anticancer Effects of Dietary Polyphenols: Chlorogenic Acid, Curcumin, Epigallocatechin-3-Gallate, Genistein, Quercetin and Resveratrol

et al. 2022

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Growing evidence has been accumulated to show the anticancer effects of daily consumption of polyphenols. These dietary polyphenols include chlorogenic acid, curcumin, epigallocatechin-3-O-gallate, genistein, quercetin, and resveratrol. These polyphenols have similar chemical and biological properties in that they can act as antioxidants and exert the anticancer effects via cell signaling pathways involving their reactive oxygen species (ROS)-scavenging activity. These polyphenols may also act as pro-oxidants under certain conditions, especially at high concentrations. Epigenetic modifications, including dysregulation of noncoding RNAs (ncRNAs) such as microRNAs, long noncoding RNAs, and circular RNAs are now known to be involved in the anticancer effects of polyphenols. These polyphenols can modulate the expression/activity of the component molecules in ROS-scavenger-triggered anticancer pathways (RSTAPs) by increasing the expression of tumor-suppressive ncRNAs and decreasing the expression of oncogenic ncRNAs in general. Multiple ncRNAs are similarly modulated by multiple polyphenols. Many of the targets of ncRNAs affected by these polyphenols are components of RSTAPs. Therefore, ncRNA modulation may enhance the anticancer effects of polyphenols via RSTAPs in an additive or synergistic manner, although other mechanisms may be operating as well.

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L-arginine attenuates Streptococcus uberis-induced inflammation by decreasing miR155 level

Gao,

Lu,

Wang

et al. 2024

International Immunopharmacology

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Propofol suppresses the growth and invasion of cervical carcinoma cells by inhibiting MIR155HG

Cited by 3 publications

References 35 publications

The effect of propofol on chemosensitivity of paclitaxel in cervical cancer cells

The effect of propofol on chemosensitivity of paclitaxel in cervical cancer cells

Contribution of Non-Coding RNAs to Anticancer Effects of Dietary Polyphenols: Chlorogenic Acid, Curcumin, Epigallocatechin-3-Gallate, Genistein, Quercetin and Resveratrol

L-arginine attenuates Streptococcus uberis-induced inflammation by decreasing miR155 level

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