2015
DOI: 10.1016/j.carpath.2014.12.004
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Propofol up-regulates expression of ABCA1, ABCG1, and SR-B1 through the PPARγ/LXRα signaling pathway in THP-1 macrophage-derived foam cells

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Cited by 36 publications
(27 citation statements)
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“…To visually observe the breakdown of lipids in LDs, we detected the co-localization between autophagosomes and LDs. Consistent with previous finding, 49 HY-SDT led to an increased number of LC3 + autophagosomes along with a decreased number of Bodipy + LDs at 6 h (Figure 5f). These results demonstrate that HY-SDT decreases lipid uptake, enhances lipid breakdown and efflux through autophagy activation via ROS-dependent TFEB nuclear translocation.…”
Section: Resultssupporting
confidence: 93%
See 1 more Smart Citation
“…To visually observe the breakdown of lipids in LDs, we detected the co-localization between autophagosomes and LDs. Consistent with previous finding, 49 HY-SDT led to an increased number of LC3 + autophagosomes along with a decreased number of Bodipy + LDs at 6 h (Figure 5f). These results demonstrate that HY-SDT decreases lipid uptake, enhances lipid breakdown and efflux through autophagy activation via ROS-dependent TFEB nuclear translocation.…”
Section: Resultssupporting
confidence: 93%
“…Fourth, cholesterol transporters are closely related to cholesterol metabolism. 3, 49 In this study, cholesterol transporter ABCA1 was increased in a time-dependent manner at both transcriptional and translational levels following HY-SDT. Simultaneously, the increased lipid efflux was significantly reversed by ABCA1 silence indicating that ABCA1 is the primary transporter responsible for the increased lipid efflux following HY-SDT.…”
Section: Discussionmentioning
confidence: 59%
“…LXR-RXR heterodimers have anti-inflammatory effects by upregulating ABCA1, ABCG1, and SR-B1 promoting the efflux of cholesterol from macrophages and thus may counter the amplification of TLR signalling by cellular cholesterol accumulation after propofol treatment 7 , 20 . However, there is no evidence to study the effect of propofol on PPARγ/LXRα pathway in RACEs.…”
Section: Discussionmentioning
confidence: 99%
“…The functions of propofol include anti-inflammatory effects, inhibition of production of proinflammatory cytokines, alteration of production of nitric oxide, inhibition of neutrophil function, and antioxidant properties 5 , 6 . Ma et al suggest that propofol up-regulates expression of ABCA1, ABCG1, and SR-B1 through the PPARγ/LXRα pathway in THP-1 macrophage-derived foam cells 7 . Moreover, propofol has a protective effect against myocardial ischemia-reperfusion injury in both normal rats and rats with type 2 diabetes, possibly by attenuating endothelial cell injury and by inhibiting the apoptosis of cardiomyocytes 8 .…”
Section: Introductionmentioning
confidence: 99%
“…en, PPARc and LXRα can affect cholesterol transport by inducing the expression of ABCA1 [18][19][20]. Previous studies have shown that PCSK9 increases expression in macrophages, causing inflammation and cholesterol accumulation by inhibiting RCT action [21,22].…”
Section: Introductionmentioning
confidence: 99%