Propofol Use for Toxin‐Related Seizures

Abstract

Propofol is being used as an anticonvulsant in poisoned patients and appears to have some utility as an adjunct in terminating toxin-related seizures once airway control has been established. Less clear, however, is at what point propofol therapy should be initiated. Prospective controlled studies are warranted to identify the role of propofol in controlling toxin-induced seizures.

Levetiracetam in toxic seizures

“…Many commonly used second line treatments lack efficacy data in drug-induced seizure or have adverse effects. Propofol is effective but may cause respiratory depression [22,23], and phenobarbital may be associated with respiratory depression and paradoxical seizures [11,24,25,26]. Phenytoin, a sodium channel blocker, may increase the risk of adverse cardiac events in amitriptyline poisoning and causes paradoxical seizures in high doses [16,27,28,29].…”