Propolis: Alternative Medicine for the Treatment of Oral Microbial Diseases

Santos, Vagner Rodrigues

doi:10.5772/54003

Cited by 32 publications

(31 citation statements)

References 148 publications

(182 reference statements)

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“…Brazilian commercial EEP formulated to ensure physical and chemical stability was also found to inhibit oral candidiasis in 12 denture-bearing patients with prosthesis-associated stomatitis and candidiasis. The available data suggest that commercial EEP could be an alternative medicine for candidiasis treatment in HIV-positive patients [16].…”

Section: Discussionmentioning

confidence: 99%

Use of Propolis for Topical Treatment of Dermatophytosis in Dog

Sánchez¹,

García²,

Zamora³

et al. 2014

OJVM

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Here we present three clinical cases of canine dermatophytosis resolved with topical propolis treatment that involved alopecia and well-demarcated erythematous lesions. These cases were positively identified by direct observation of samples from the affected zones with 10% KOH. Each sample was cultured, leading to the isolation of Microsporum gypseum in one case and Microsporum canis in the other two cases. The animals' subsequent treatment included bathing using a commercial soap with propolis every seven days for 3 to 8 weeks, as well as the use of a propoliscontaining ointment elaborated in our laboratory, which was applied to the lesions once a day for three weeks. From the second week of treatment, all cultures were negative. At the end of treatment, all cases displayed full recovery of the injuries and hair growth in these areas. In these clinical cases, treatment with propolis was effective, supporting the use of propolis as a promising natural alternative with no known collateral effects.

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Section: Discussionmentioning

confidence: 99%

Use of Propolis for Topical Treatment of Dermatophytosis in Dog

Sánchez¹,

García²,

Zamora³

et al. 2014

OJVM

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“…Green propolis collected in the southern region of Brazil belongs to Group 12 (propolis G12), as twelve distinct groups of Brazilian propolis have been classified according to their botanical origin and biological properties: five from the south, six from the northeast, and one from the southeast named propolis “green” [ 26 , 30 ]. However, only three types of Brazilian propolis had their botanical origin and chemical constituents identified [ 31 ]. One of these confirmed propolis types is the studied green propolis from Minas Gerais State in southeast Brazil, which is derived mainly from alecrim plants Baccharis dracunculifolia (Asteraceae).…”

Section: Methodsmentioning

confidence: 99%

The Assessment of Oral Microflora Exposed to 3% Ethanolic Extract of Brazilian Green Propolis Preparation Used for Hygiene Maintenance following Minor Oral Surgeries

Morawiec

Mertas

Wojtyczka

et al. 2015

BioMed Research International

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The aim of this study was to investigate the influence of a topically administered hygienic preparation containing a 3% ethanolic extract of Brazilian green propolis (EEP-B) on oral microflora spectrum changes in a group of patients who underwent common oral surgery procedures. Two gel samples were compared: the tested gel containing an active ingredient, that is, a 3% EEP-B (gel GA), and a placebo as the negative control (gel GC). The collection of microbiological material included 14 patients requiring surgical extraction of wisdom molars and short endosseous implant installation. Clinical examinations were carried out as follow-up, that is, baseline and after 5-6 weeks' time. During the first and subsequent assessment, swabs were taken from the mucosal surface. The number of microorganism species was found to have increased following the application of GC gel over the period of 5-6 weeks. This mainly affected Gram-positive rods and bacilli as well as Gram-negative rods. Application of the GA gel enriched with 3% EEP-B caused a profound reduction in the amount of Neisseria spp. and Bifidobacterium spp. strains. Elimination of seven species of microorganisms was observed: Streptococcus acidominimus, Streptococcus oralis, Staphylococcus epidermidis, Veillonella parvula, Bifidobacterium breve, Bifidobacterium longum, and Lactobacillus acidophilus.

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“…It contains more than 300 natural compounds such as polyphenols, phenolic aldehydes, sequiterpene-quinones, coumarins, amino acids, steroids and inorganic compounds. Propolis exhibits a broad spectrum of biological and pharmacological properties such as antimicrobial, antioxidant, anti-inflammatory, immunomodulatory, antitumor, anticancer, antiulcer, hepatoprotective, cardioprotective, and neuroprotective actions [11][12][13]. The chemical composition and beneficial properties of propolis vary greatly depending on the phytogeographical areas, seasonal collection time, and botanical source [14].…”

Section: Introductionmentioning

confidence: 99%

Mucoadhesive Propolis Gel for Prevention of Radiation-Induced Oral Mucositis

Noronha¹,

Sivieri-Araújo²,

Gomes³

et al. 2014

CCP

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The objective of this phase II study was to determine the effectiveness of a mucoadhesive propolis gel in the prevention of radiation-induced oral mucositis. Twenty-four patients who were selected to undergo radiation therapy for oral cancer were included in this open-label trial. They were advised to use a mucoadhesive gel containing propolis 5,0% w/v three times a day starting one day before the course of radiation therapy and concluding after 2 weeks of radiation therapy. A weekly follow-up for evaluation of food intake, pain and grading of mucositis was performed. In order to confirm the absence of Candida-related mucositis in patients who developed mucositis, it was performed exfoliative cytology of buccal mucosa, palate and tongue and the material for Candifast(®) Candida species identification. At the end of the study was made the compliance of patients, quality, appreciation and acceptance of product evaluation. Twenty patients did not develop mucositis, two patients developed grade 1 mucositis and two patients developed grade 2 mucositis. None of the patients discontinued food intake and no pain was observed during the study. Candidosis was not detected in any patient. Mucoadhesive propolis gel could be considered as a potential topical medication for preventing radiation-induced oral mucositis. However, comparative phase III study with larger number of patients should be done for confirmation of the efficacy of the product.

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Propolis: Alternative Medicine for the Treatment of Oral Microbial Diseases

Cited by 32 publications

References 148 publications

Use of Propolis for Topical Treatment of Dermatophytosis in Dog

Use of Propolis for Topical Treatment of Dermatophytosis in Dog

The Assessment of Oral Microflora Exposed to 3% Ethanolic Extract of Brazilian Green Propolis Preparation Used for Hygiene Maintenance following Minor Oral Surgeries

Mucoadhesive Propolis Gel for Prevention of Radiation-Induced Oral Mucositis

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