Propolis Attenuates Doxorubicin-Induced Testicular Toxicity in Rats

Rizk, Sherine M.; Zaki, Hala F.; Mina, Mary A.M.

doi:10.1016/j.fct.2014.02.031

Cited by 109 publications

(99 citation statements)

References 52 publications

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“…Moreover, treatment with propolis extract prevented CsA-induced reduction in sperm motility and, it increased sperm motility of rats in the propolis group (P < 0.01; Table 3). Consistent with the present results, Capucho et al (2012) and Rizk et al (2014) reported that propolis extract can increase the sperm count of rats. According to these findings, propolis may be have an adjuvant therapy.…”

Section: Discussionsupporting

confidence: 81%

“…Testicular tissue that induced by CSA was protected from oxidation by propolis administration. Rizk et al (2014) reported that administration of propolis extract to normal rats increased sperm count by 31.20% as compared with the control group. Sperm motility may be affected by altered enzymatic activities of oxidative phosphorolytic process.…”

Section: Discussionmentioning

confidence: 99%

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The effects of propolis on sperm quality, reproductive organs and testicular antioxidant status of male rats treated with cyclosporine-A

Baykalır¹,

Seven²,

Gür³

et al. 2016

Anim Reprod

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This study was designed to determine the effects of propolis on the quality of sperm and reproductive organs in male rats treated with cyclosporine-A. In this study, 24 male Sprague-Dawley rats (280-300 g BW) at 8-10 weeks of age were used. The rats were randomly divided into control and 3 treatment groups. Each rat was placed into a cage. During 21 days (experimental period), Group 1 served as control group; Group 2 (CsA) was given 15 mg/kg BW/day of CsA by subcutaneously; Group 3 (P) was given 100 mg/kg BW/day of propolis by gavage; Group 4 (CsA+P) was given 15 mg/kg BW/day of CsA subcutaneously and 100 mg/kg BW/day of propolis by gavage. Administration of CsA to rats decreased sperm motility (P < 0.01) and sperm concentration (P < 0.01), and it increased total abnormal sperm rates (P < 0.05) as compared with the control group. Significant improvements were observed in the sperm motility (P < 0.01) and total abnormal sperm rates (P < 0.05) in CsA+P group. No significant differences were observed in the weights of right and left testes among all groups. The weight values of right and left epididymis were found similar to each other in CsA administrated groups. Seminal vesicle (P < 0.01) and prostat glands weights (P < 0.01) were significantly higher in CsA+P group than CsA group. As a result, it was determined that oral supplementation of 100 mg/kg of propolis had amendatory effect on the quality of sperm and reproductive organs treated with CsA administered rats. CsA treatment caused a significant increase in MDA level (P < 0.01) and significant decreases (P < 0.01) in GSH level and CAT activity when compared with the control group. Ingestion of propolis by CsA-treated rats significantly decreased the MDA level and significantly increased the GSH level when compared with the CsA alone group (P < 0.01).

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Section: Discussionsupporting

confidence: 81%

Section: Discussionmentioning

confidence: 99%

The effects of propolis on sperm quality, reproductive organs and testicular antioxidant status of male rats treated with cyclosporine-A

Baykalır¹,

Seven²,

Gür³

et al. 2016

Anim Reprod

View full text Add to dashboard Cite

show abstract

“…somatic cells that interact directly with developing germ cells (GCs) throughout this process (29). Moreover, it is well-documented that the optimum level of testosterone is necessary for ordinary spermatogenesis and GC structural development, as well as the normal histophysiology of the seminiferous tubules (30). In support of these facts, it seems that FLX-evoked disruption of testosteronedependent GC maturation events can result in defective spermatogenesis, leading to considerable alterations in testicular histopathology and histomorphometric parameters.…”

Section: Discussionmentioning

confidence: 75%

Black Grape Seed Extract Modulates Fluoxetine-Induced Oxidative Stress and Cytotoxicity in the Mouse Testis

Hajizadeh

Mehranjani

Najafi

et al. 2016

Jundishapur J Nat Pharm Prod

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Background: Fluoxetine (FLX), a selective serotonin reuptake inhibitor, is widely used in the treatment of neurological disorders. However, its application carries the risk of adverse reactions, including reproductive toxicities. Grape seed is highly regarded for its pharmacological activities, specifically its antioxidant properties. Objectives: This study was designed to evaluate whether hydroalcoholic grape seed extract (GSE) could ameliorate FLX-evoked oxidative injuries in the mouse testis. Materials and Methods: Thirty-two male mice were categorized into four groups of eight mice each. Two groups received FLX at a dose of 20 mg/kg per day over a period of six weeks by oral gavage. One of these groups received GSE at a dose of 100 mg/kg per day orally along with the FLX. An untreated control group and a GSE-only treated group were also included. Serum and testicular samples were collected 24 hours after the last treatment. Results: Biochemical analyses demonstrated that FLX caused significant decreases in testicular antioxidant capacity and serum testosterone concentrations, as well as lipid peroxidation elevations in testicular tissue. Morphometric and histopathological studies supported the biochemical findings. Concomitant administration of GSE with FLX markedly reduced testicular damage and significantly restored all of the mentioned markers to normal values. Conclusions:The findings suggested that oxidative stress-mediated testicular damage, arising as a result of FLX administration in mice, could be reversed by GSE.

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“…Oxidative stress induced by Cd is believed to be one of important factors in Cd induced testicular damage as evidenced by increase testicular MDA, depletion of antioxidant mechanism in testes and DNA damage of rats inject S/C with Cd (0.4mg/kg) 66 . In this experimental model concomitant treatment of Cd-intoxicated rats with propolis resulted in restoration of testicular tissue to normal such protective effect of propolis on testes was previously recorded against profenofos 58 , doxorubicin 67 due to its antioxidant properties.…”

Section: Histopathological Examination Of Testesmentioning

confidence: 99%

Assessment of Beneficial Effect of Propolis against Cadmium Induced Toxicity and Oxidative Stress in Rats.

2017

JCBSC

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Propolis Attenuates Doxorubicin-Induced Testicular Toxicity in Rats

Cited by 109 publications

References 52 publications

The effects of propolis on sperm quality, reproductive organs and testicular antioxidant status of male rats treated with cyclosporine-A

The effects of propolis on sperm quality, reproductive organs and testicular antioxidant status of male rats treated with cyclosporine-A

Black Grape Seed Extract Modulates Fluoxetine-Induced Oxidative Stress and Cytotoxicity in the Mouse Testis

Assessment of Beneficial Effect of Propolis against Cadmium Induced Toxicity and Oxidative Stress in Rats.

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