Propolis protects CYP 2E1 enzymatic activity and oxidative stress induced by carbon tetrachloride

Bhadauria, Monika; Nirala, Satendra Kumar; Shukla, Sangeeta

doi:10.1007/s11010-007-9443-4

Cited by 53 publications

(37 citation statements)

References 35 publications

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“…Silymarin at doses up to 100 mg/ kg has been used as a standard hepatoprotective agent by numerous investigators. Dose of 50 mg/kg of silymarin was selected in the present investigation based on some published studies demonstrating the hepatoprotective activity of this dose (Boigk et al, 1997;Bhadauria et al, 2007). In the present study, silymarin was used as the standard to compare the activity of both of the extracts.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of hepatoprotective activity of aqueous and ethanolic extract of Oxalis corniculata against intoxication of thioacetamide induced rats

Das¹,

Kathiriya²,

P³

et al. 2012

Rev. bras. farmacogn.

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Abstract:The present study was carried out to evaluate the hepatoprotective activity of aqueous and ethanolic leaves extracts of Oxalis corniculata L., Oxalidaceae, against thioacetamide-induced hepatotoxicity. Hepatotoxicity was induced in Wistar rats of either sex by subcutaneous injection of thioacetamide. .37 IU/L respectively) and total bilirubin (0.226±0.00 mg/dL 0.288±0.01 mg/dL respectively) content that were lesser than positive control, thioacetamide damaged rats. Histology of the liver sections of the animals treated with the extract also showed dose dependent reduction of necrosis. Hence the study concluded that O. corniculata has potential hepatoprotective activity.

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Section: Discussionmentioning

confidence: 99%

Evaluation of hepatoprotective activity of aqueous and ethanolic extract of Oxalis corniculata against intoxication of thioacetamide induced rats

Das¹,

Kathiriya²,

P³

et al. 2012

Rev. bras. farmacogn.

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“…with vehicle (olive oil) 10 . An aqueous suspension of extract was prepared in distilled water and selected optimum dose was administered (800 mg/kg, p.o.)…”

Section: Preparation Of Doses and Treatmentsmentioning

confidence: 99%

Curative Effect of Butea Monosperma (Lam.) Flowers on Ccl4 Induced Subchronic Hepatic Injury in Rat Model

Sharma¹,

Shukla²

2018

Int. J. Res. Ayurveda Pharm.

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Butea monosperma (B. monosperma) Lam. is commonly known as Palash in Hindi and their flower are used to treat leprosy, gout, skin, eye diseases and has been reported to be associated with various remedial properties such as antihepatotoxic, antistress, antiestrogenic and chemopreventive. In the present study, hepatoprotective effects of B. monosperma (800 mg/kg p.o.) was studied against biochemical, light and ultrastructural and genotoxic changes induced by carbon tetrachloride (CCl4, 0.15 ml/kg, i.p.). Subchronic exposure to CCl4 for 3 weeks caused sharp elevation in the activity of liver marker enzymes (serum transaminases, alkaline phosphatase and lactate dehydrogenase), albumin, bilirubin, creatinine and urea level in serum. Tissue biochemistry revealed significant reduction in antioxidant status i.e. glutathione reductase, glutathione peroxidase, super oxide dismutase and catalase. Oxidative stress was measured by estimating reduced glutathione level and amount of thiobarbituric acid reactive substances. CCl4 administration significantly decreased aniline hydroxylase activity and increased microsomal lipid peroxidation. A 5-day treatment of B. monosperma extract after toxicant administration reversed alterations in blood and tissue biochemical variables almost as same as in silymarin treated positive control. In conclusion, data suggest aqueous extract of B. monosperma prevent hepatic damage and improved cellular architecture through its antioxidant activity.

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“…Ancient Egyptians, used propolis for embalming their dead, and Greeks used it to cure external and internal sores and ulcers due to its anti-inflammatory and healing properties [2]. It exhibits a wide range of biological activities such as anti-oxidant [3], anti-bacterial [4], anti-viral [5], anti-fungal [6], antiparasitic [7], anti-inflammatory activities [8] and as hepatoprotective agent against carbon tetrachloride induced hepatotoxicity [9]. These biological activities are based on its rich phenolic, flavonoid and trepenoid contents [10].…”

Section: Introductionmentioning

confidence: 99%

Antioxidant activity and protective effects of commercial propolis on gentamicin induced nephrotoxicity in rabbits- In vitro study

Osman¹,

Tantaway²

2013

Turk J Bioch

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Propolis protects CYP 2E1 enzymatic activity and oxidative stress induced by carbon tetrachloride

Cited by 53 publications

References 35 publications

Evaluation of hepatoprotective activity of aqueous and ethanolic extract of Oxalis corniculata against intoxication of thioacetamide induced rats

Evaluation of hepatoprotective activity of aqueous and ethanolic extract of Oxalis corniculata against intoxication of thioacetamide induced rats

Curative Effect of Butea Monosperma (Lam.) Flowers on Ccl4 Induced Subchronic Hepatic Injury in Rat Model

Antioxidant activity and protective effects of commercial propolis on gentamicin induced nephrotoxicity in rabbits- In vitro study

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