Propolis relieves the cardiotoxicity of chlorpyrifos in diabetic rats via alleviations of paraoxonase-1 and xanthine oxidase genes expression

Ibrahim, Khairy A.; Khwanes, Soad A.; El-Desouky, Mohamed A.; Elhakim, Heba K.A.

doi:10.1016/j.pestbp.2019.06.006

Cited by 25 publications

(10 citation statements)

References 60 publications

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“…Oxidative stress results in an imbalance between oxidants and antioxidants that is known to be closely associated with various diseases. A study has shown that PE reduces oxidative stress by increasing antioxidant enzyme activities, although increased PC levels were not observed for diabetes treated with PE . Although PC was significantly increased by the administration of PE to C6 glioma cells in the present study, TOS was insignificantly decreased.…”

Section: Discussioncontrasting

confidence: 82%

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Cytotoxic and apoptotic effects of ethanolic propolis extract on C6 glioma cells

Coşkun

Ersöz

Gecili

et al. 2020

Environmental Toxicology

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Propolis is a natural resinous substance obtained from beehives, and emerging evidence supports that it has antitumor, antiinflammatory, antioxidant, and antimicrobial activities. The aim of the study is to examine the cytotoxic, antioxidant, and apoptotic features of ethanolic propolis extract (PE) on C6 glioma cells. The cells were treated with ethanolic PE at various concentrations for 24 hours, after which the total antioxidant status (TAS) and total oxidant status; malondialdehyde, protein carbonyl, 8-hydroxy-2 0 -deoxyguanosine, and glutathione (GSH) levels; Cu/Zn-superoxide dismutase (Cu/Zn-SOD) activity; and apoptotic markers were measured. Ethanolic PE at 100, 250, and 500 μg/mL concentrations showed optimal activity on C6 glioma cells.TAS and GSH levels were significantly increased in C6 glioma cells treated with 100 and 500 μg/mL PE compared to control cells (P < .05). Similarly, the activity of Cu/Zn-SOD was higher in C6 glioma cells treated with 250 or 500 μg/mL ethanolic PE compared to control cells (P < .05), as was the caspase-3 mRNA expression level.The highest levels of caspase-8 and -9 expression were in C6 glioma cells treated with 500 μg/mL PE. Collectively, our results indicate that ethanolic PE has cytotoxic and apoptotic effects on C6 glioma cells. Furthermore, it may provide a protective role in the antioxidant defense system. PE shows potential for development as a natural antioxidant and apoptotic agent for the treatment of brain tumors. K E Y W O R D Santioxidant, brain tumor, cell death, cytotoxicity, propolis

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Section: Discussioncontrasting

confidence: 82%

“…Many studies have revealed that PE alone and in combination with other materials has the potential to improve the antioxidant capacity in various disease states . Oxidative stress results in an imbalance between oxidants and antioxidants that is known to be closely associated with various diseases.…”

Section: Discussionmentioning

confidence: 99%

Cytotoxic and apoptotic effects of ethanolic propolis extract on C6 glioma cells

Coşkun

Ersöz

Gecili

et al. 2020

Environmental Toxicology

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“…Thus, the antioxidation abilities of tissues can be tested to elucidate intrinsic anti-diabetes properties. For this purpose, amounts of antioxidant enzymes such as GPx, CAT, superoxide dismutase (SOD), glutathione S-transferase (GST), and antioxidant glutathione (GSH) have often been measured [131,132,133,134,135,136,137,138,139,140,155,157,162,202]. Alternatively, oxidation of polyunsaturated fatty acids is also measured to evaluate oxidative stress in diabetic animals.…”

Section: Diabetes Mellitusmentioning

confidence: 99%

“…Gavage of Taiwanese green propolis (919.5 mg/kg/day for 8 weeks) decreased serum TNF-α, IL-1β, and IL-6, while a lower dose (183.9 mg/kg/day) caused milder responses in TNF-α and IL-1β levels [159]. Similarly, administration of Saudi Arabian and Egyptian propolis extracts also diminished the increase of circulating IL-6 in STZ-induced diabetic animals [135,140]. Flavonoids or phenols in propolis also modify circulating cytokine levels in vivo.…”

Section: Diabetes Mellitusmentioning

confidence: 99%

Effects of Propolis Extract and Propolis-Derived Compounds on Obesity and Diabetes: Knowledge from Cellular and Animal Models

Kitamura

2019

Molecules

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Propolis is a natural product resulting from the mixing of bee secretions with botanical exudates. Since propolis is rich in flavonoids and cinnamic acid derivatives, the application of propolis extracts has been tried in therapies against cancer, inflammation, and metabolic diseases. As metabolic diseases develop relatively slowly in patients, the therapeutic effects of propolis in humans should be evaluated over long periods of time. Moreover, several factors such as medical history, genetic inheritance, and living environment should be taken into consideration in human studies. Animal models, especially mice and rats, have some advantages, as genetic and microbiological variables can be controlled. On the other hand, cellular models allow the investigation of detailed molecular events evoked by propolis and derivative compounds. Taking advantage of animal and cellular models, accumulating evidence suggests that propolis extracts have therapeutic effects on obesity by controlling adipogenesis, adipokine secretion, food intake, and energy expenditure. Studies in animal and cellular models have also indicated that propolis modulates oxidative stress, the accumulation of advanced glycation end products (AGEs), and adipose tissue inflammation, all of which contribute to insulin resistance or defects in insulin secretion. Consequently, propolis treatment may mitigate diabetic complications such as nephropathy, retinopathy, foot ulcers, and non-alcoholic fatty liver disease. This review describes the beneficial effects of propolis on metabolic disorders.

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“…Propolis contains a lot of flavonoids and polyphenols which correlates with its physiological activity, such as anti-inflammatory, antioxidant and immunomodulatory activities ( Zabaiou et al, 2017 ). A recent study has shown that propolis intake may reduce the risk of cardiovascular diseases caused by chlorpyrifos exposure by the improvement of PON1 and XO mRNA genes regulation leading to the accumulation of the cellular enzymatic and/or non-enzymatic antioxidants ( Ibrahim et al, 2019 ). Pomegranate ( Punica granatum L.) is a common fruit rich in polyphenols such as ellagic acid and ellagitannin.…”

Section: Protective Effects Of Natural Products Against Environmental Toxins-induced Cardiotoxicitymentioning

confidence: 99%

Recent Progress in Environmental Toxins-Induced Cardiotoxicity and Protective Potential of Natural Products

et al. 2021

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Humans are unconsciously exposed to environmental toxins including heavy metals as well as various pesticides, which have deleterious effects on human health. Accumulating studies pointed out that exposure to environmental toxins was associated with various cardiopathologic effects. This review summarizes the main mechanisms of cardiotoxicity induced by environmental toxins (cadmium, arsenic and pesticides) and discusses the potential preventive effects of natural products. These findings will provide a theoretical basis and novel agents for the prevention and treatment of environmental toxins-induced cardiotoxicity. Furthermore, the limitations of current studies, future needs and priorities are discussed.

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Propolis relieves the cardiotoxicity of chlorpyrifos in diabetic rats via alleviations of paraoxonase-1 and xanthine oxidase genes expression

Cited by 25 publications

References 60 publications

Cytotoxic and apoptotic effects of ethanolic propolis extract on C6 glioma cells

Cytotoxic and apoptotic effects of ethanolic propolis extract on C6 glioma cells

Effects of Propolis Extract and Propolis-Derived Compounds on Obesity and Diabetes: Knowledge from Cellular and Animal Models

Recent Progress in Environmental Toxins-Induced Cardiotoxicity and Protective Potential of Natural Products

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