Proportion Of Antidepressants Prescribed Without A Psychiatric Diagnosis Is Growing

Mojtabai, Ramin; Olfson, Mark

doi:10.1377/hlthaff.2010.1024

Cited by 208 publications

(201 citation statements)

References 28 publications

Supporting

Mentioning

188

Contrasting

Unclassified

Order By: Relevance

“…However, studies have shown that a high proportion of prescriptions for psychotropic medications such as anxiety medications fail to have a corroborating diagnosis in the medical record. [15][16][17] Our data do not allow confirmation via medical records or other sources.…”

Section: Discussionmentioning

confidence: 96%

Use of Psychotropic Medication in Children and Adolescents With Autism Spectrum Disorders

et al. 2012

View full text Add to dashboard Cite

OBJECTIVES: The goal of this study was to examine rates of psychotropic medication use and identify associated child and family characteristics among children and adolescents with autism spectrum disorder (ASD) enrolled in an autism registry maintained by the Autism Treatment Network (ATN). METHODS:The sample, derived from the ATN registry, consists of 2853 children aged 2 to 17 years with diagnoses of ASD supported by Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, and the Autism Diagnostic Observation Schedule with available data on medication use. As part of initial enrollment in the registry, parents completed questionnaires on current psychotropic medication use, psychiatric and medical conditions, and demographics. RESULTS:Of the 2853 children, 763 (27%) were taking $1 psychotropic medication; 15% were prescribed 1 medication, 7.4% received 2 medications, and 4.5% received $3. Among children aged 3 to 5 years, 11% were taking $1 psychotropic medication; among 6-to 11-year-old children, 46%; and 66% of adolescents aged 12 to 17 years were taking at $1 psychotropic medication. A parent report of comorbid diagnosis of attention-deficit/hyperactivity disorder, bipolar disorder, obsessive-compulsive disorder, depression, or anxiety was associated with a high rate of use, with 80% receiving $1 psychotropic medication. Only 15% of children with no comorbid psychiatric disorder were taking psychotropic medication. Psychotropic medication use was also related to sleep and gastrointestinal problems. CONCLUSIONS:The prescription of psychotropic medications in this registry sample is highly related to comorbid psychiatric disorder. Other factors associated with use include medical comorbidities, race, ethnicity, and older age. Pediatrics 2012;130:S69-S76

show abstract

Section: Discussionmentioning

confidence: 96%

Use of Psychotropic Medication in Children and Adolescents With Autism Spectrum Disorders

et al. 2012

View full text Add to dashboard Cite

show abstract

“…Tamoxifen potentiates the 103,109 Antidepressants are one of the most commonly prescribed medications in the US. [110][111][112] Commonly prescribed antidepressants classified as selective serotonin reuptake inhibitors (SSRIs) inhibit the enzyme CYP2D6 and thus may slow the metabolism of tamoxifen, resulting in a decrease of its potency and thereby increasing the risk of recurrence. [113][114][115][116] Aromatase Inhibitors: Letrozole, Anastrozole, and Exemestane: Aromatase inhibitors (AIs) work by blocking the enzyme aromatase, which converts adrenal androgens into estrogens.…”

Section: Hormonal Blockadementioning

confidence: 99%

Breast Cancer Survivorship: A Comprehensive Review of Long-Term Medical Issues and Lifestyle Recommendations

Bodai¹,

Tuso

2015

TPJ

286

163

View full text Add to dashboard Cite

“…Selective serotonin reuptake inhibitors (SSRIs) are a class of small molecules that are highly selective for SERT over DAT and NET and that inhibit 5-HT reuptake with nanomolar potency 16 . SSRIs are typically used as antidepressants in the treatment of major depressive disorder and anxiety disorder 1 and are the most widely prescribed antidepressants 17 .…”

Section: Main Textmentioning

confidence: 99%

Structural basis for recognition of diverse antidepressants by the human serotonin transporter

Coleman

Gouaux

2017

Preprint

View full text Add to dashboard Cite

Selective serotonin reuptake inhibitors are clinically prescribed antidepressants that act by increasing the local concentration of neurotransmitter at synapses and in extracellular spaces via blockade of the serotonin transporter. Here we report x-ray structures of engineered thermostable variants of the human serotonin transporter bound to the antidepressants sertraline, fluvoxamine, and paroxetine. The drugs prevent serotonin binding by occupying the central substrate binding site and stabilizing the transporter in an outward-open conformation.These structures explain how residues within the central site orchestrate binding of chemically diverse inhibitors and mediate transporter-drug selectivity. MAIN TEXTIn the central nervous system the serotonin transporter (SERT) modulates serotoninergic signaling by carrying out the uptake of serotonin (5-HT) from the synaptic space into presynaptic . An extracellular vestibule in the outward-facing conformation 7,9,10 forms a secondary, allosteric site which, when occupied by ligands, can result . CC-BY-NC-ND 4.0 International license peer-reviewed) is the author/funder. It is made available under a The copyright holder for this preprint (which was not . http://dx.doi.org/10.1101/204859 doi: bioRxiv preprint first posted online Oct. 17, 2017; page 3 of 15 in modulation of transporter activity by altering the kinetics of ligand dissociation from the central site [11][12][13] . Addictive substances such as cocaine and amphetamine bind to monoamine transporters and can either inhibit NT transport or promote NT efflux, respectively 14,15 . Selective serotonin reuptake inhibitors (SSRIs) are a class of small molecules that are highly selective for SERT over DAT and NET and that inhibit 5-HT reuptake with nanomolar potency Fig. 1), and as a consequence these compounds bind with a range of affinities to SERT. Sertraline contains a tetrahydronaphthalene ring system linked to a secondary amine together with a meta and para substituted dichlorophenyl group. Fluvoxamine, by contrast, consists of a 2-aminoethyloxime moiety attached to a methyoxybutyl group, and a phenyl group containing a trifluoronated methyl at the para positon. Fluoxetine also contains a trifluoronated aromatic group but is instead coupled to a phenylpropylamine moiety. Paroxetine and citalopram also differ substantially in the structures of their aromatic, amine, and halogenated substitutents.Recently, we solved x-ray structures of a thermostabilized, transport-inactive construct of human SERT, deemed the ts3 construct, in complex with the SSRIs paroxetine and citalopram 8 .We employed the thermostabilized variant of SERT in order to facilitate purification and crystallization 19,20 . One of the thermostabilizing mutations, however, involves a residue (Thr439Ser) that is directly positioned within the central binding site, in close proximity to the bound SSRIs. Moreover, recent computational modeling of a wild-type SERT-paroxetine complex, in which the structure of the Drosophila DAT was used as a ...

show abstract

Proportion Of Antidepressants Prescribed Without A Psychiatric Diagnosis Is Growing

Cited by 208 publications

References 28 publications

Use of Psychotropic Medication in Children and Adolescents With Autism Spectrum Disorders

Use of Psychotropic Medication in Children and Adolescents With Autism Spectrum Disorders

Breast Cancer Survivorship: A Comprehensive Review of Long-Term Medical Issues and Lifestyle Recommendations

Structural basis for recognition of diverse antidepressants by the human serotonin transporter

Contact Info

Product

Resources

About