INTRODUCTIONDiabetes mellitus is a group of metabolic disorders characterized by chronic hyperglycemia associated with disturbances of carbohydrate, fat and protein metabolism due to absolute or relative deficiency in insulin secretion and/or action.1 It is categorized into type 1 and type 2 diabetes mellitus. Type 1 Diabetes mellitus usually manifests before adulthood and accounts for about 5% of the cases. It arises through the autoimmune destruction of pancreatic beta cells, which leaves the patient with severe insulinopenia and extreme hyperglycemia. Type 2 diabetes mellitus (T2DM usually manifests in later adult life and accounts for about 95% of all cases. It develops mainly through a combination of insulin resistance and defective beta cell function. T2DM if not treated adequately, can lead to micro-vascular complications affecting the retina, renal glomerulus and the peripheral ABSTRACT Background: Type 2 diabetes mellitus (T2DM) and depressive disorders are among the major health problems in our community. Chronic medical conditions, like diabetes are affectively stressful for patients and may influence pathophysiologic mechanisms as well as mood. This can lead to depression and poor prognosis of T2DM. This study was done to assess the prevalence of depression among T2DM patients and its association with glycemic control. Methods: This descriptive cross sectional study was carried out among 300 T2DM patients attending Urban Health Training Center (UHTC), Anakaputhur, which belongs to the urban field practice area of our institution. Fasting Blood Sugar levels (FBS) were assessed retrospectively from their medical records; and they were screened for depression by administering the nine items, "Patient Health Questionnaire -9". Results: Of the 300 T2DM patients, 54% were females. The mean age of the participants was 53±9.7 years. 31% of the study participants had fasting blood sugar (FBS) levels above 125 mg/dl. Depression was present in 39.7% of the individuals, among which, 17.3% had mild depression, 13% had moderate depression, 6.7% had moderately severe depression and 2.7% had severe depression. Depression was found to be significantly associated with increasing fasting blood sugar levels, diabetic complications, female gender and diabetic treatment. Conclusions: This study shows that depression is highly prevalent among T2DM patients and is associated with poor prognosis, as reflected by poor glycemic control (FBS) and the occurrence of diabetic complications. So screening and counselling for depression among T2DM patients have to be carried out for optimum control and treatment of T2DM.