Objective: This study aims to analyze the prevalence of HIV positive serology in trans women sex workers, and the main problems associated. Methods: Scientific articles were found searching data platforms (PubMed, Virtual Health Library, Web of Science and Google Scholar) as much as much as epidemiological bulletins and statistical data from the Ministério da Saúde do Brasil (Ministry of Health) and UNAIDS were included. Results: Gender violence and gender inequality can contribute to the increased vulnerability of the transgender population to HIV. Globally, trans women are 50 times more likely to be infected with HIV, with seroprevalence in Brazil ranging from 16.9% to 65.3%. Studies point to prostitution as one of the main causes of seroconversion in trans women, especially between the ages of 18 and 24 years. Due to the immense marginalization, transsexual women have an evident difficulty in entering the labor market and accessing basic rights, such as health. These factors contribute to a greater vulnerability to HIV infection. Conclusion: The Ministry of Health needs to improve more incisively the prevention and assessment strategies of the risk levels of HIV transmission, without perpetuating gender violence, including by making it invisible, which contributes to maintaining the vulnerability of the professional transsexual population of sex.