Proportional change of CD4+CD25+ regulatory T cells after lymphocyte therapy in unexplained recurrent spontaneous abortion patients

Adaptive Immune Responses During Pregnancy

“…In the last years, the idea of paternal antigens leading to a protective Treg-mediated immune response was confirmed in studies where Treg increase after paternal lymphocyte immunization therapy 119 or in vitro fertilization treatment. 120 This information is very useful and may lead to re-think about the so controversial therapy with paternal leukocytes 121 and to dissect which patients should be treated.…”

Th17 and Regulatory T cells in Women with Recurrent Pregnancy Loss

“…Lymphocyte immunotherapy (LIT) with paternal or third-party lymphocytes has been demonstrated to increase CD4 + CD25 bright T cells. 71 The proportion of these CD4 + CD25 bright T cells was higher in women with a successful pregnancy than in women with pregnancy loss after LIT. The presence of intravenous immunoglobulin with human CD4 + CD25 + regulatory T cells in culture significantly increased the expression of Foxp3, TGF-b, and IL-10.…”

What is wrong with the regulatory T cells and foetomaternal tolerance in women with recurrent miscarriages?

“…The latest Cochrane review by Wong et al showed that none of these treatments provided a significant beneficial effect over placebo in improving the live birth rate or reducing the risk of future miscarriage in women who had RM . Nevertheless, some studies showed that the proportion of CD4+CD25high T cells in peripheral blood from women with unexplained RM was significantly increased after paternal or third‐party lymphocyte immunization therapy , and 80–90% of patients who underwent immunotherapy successfully delivered a baby . Furthermore, the proportion of Tregs was significantly higher in successfully pregnant women than in those with pregnancy loss after lymphocyte therapy .…”