Let K be an isotropic 1-unconditional convex body in R n . For every N > n consider N independent random points x1, . . . , xN uniformly distributed in K. We prove that, with probability greater than 1 − C1 exp(−cn) if N ≥ c1n and greater than 1 − C1 exp(−cn/ log n) if n < N < c1n, the random polytopes KN := conv{±x1, . . . , ±xN } and SN := conv{x1, . . . , xN } have isotropic constant bounded by an absolute constant C > 0.