A total of 27 clinically diagnosed bovine dwarfs were submitted as part of a continuous investigation into the frequency, nature, and cause of congenital defects in cattle. The dwarfs varied in age, sex, breed, and phenotypic appearance. Haematological, enzymological and karyotype findings were not significantly different from normal calves. Macroscopic findings were variable. Four calves had small or cystic pituitary glands and were suspected to be pituitary-type dwarfs. One had chronic renal disease and elevated plasma somatomedin-C levels and was considered a renal-type dwarf. Two calves had thymic lymphosarcoma, which could account for thymic-associated dwarfism. Four calves had chronic debilitating diseases (one mesothelioma, two pleuropneumonia, and one omental bursitis) which could explain the abnormal growth. Reasons for dwarfism in the other 14 calves were not determined.Histological, biochemical, and radiological evidence, and the possible inheritance pattern in two "bulldog" type Holstein dwarfs indicated a similarity to human achondrogenesis type I1 dwarfism and so this condition might be a good model for human chondrodystrophy.