Proportions of Mouse Erythrocyte Rosette-Forming Lymphocytes, Immunoglobulin-Bearing Cells and E Rosettes in Patients with Lymphoproliferative Diseases

Hunyadi, J.; Husz, S.; Kenderessy, Anna Sz.; Simon, N.

doi:10.1159/000207823

Acta Haematol

1977

DOI: 10.1159/000207823

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Proportions of Mouse Erythrocyte Rosette-Forming Lymphocytes, Immunoglobulin-Bearing Cells and E Rosettes in Patients with Lymphoproliferative Diseases

J. Hunyadi¹,

S. Husz²,

Anna Sz. Kenderessy³

et al.

Abstract: The proportions of mouse erythrocyte rosette-forming (MERF) lymphocytes, immunoglobulin (Ig)-bearing cells and E rosettes were examined in the peripheral blood of patients with lymphoproliferative diseases. The proportion of MERF lymphocytes was considerably increased in chronic lymphocytic leukaemia. The correlation between the proportions of MERF and Ig-bearing cells, characteristic of healthy individuals, is not observed in the lymphoproliferative diseases. It is suggested that in a part of the patients wit… Show more

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1981

1984

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T cells and erythroid burst forming units in chronic lymphocytic leukemia

Socinski

Ershler

1984

American J Hematol

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Substantial evidence exists indicating T cell abnormalities in chronic lymphocytic leukemia (CLL). There is also evidence that the T cell is an important source of burst promoting activity (BPA) for the peripheral blood (PB) erythroid burst forming unit (BFU-e). We studied the BPA of T cells and response of BFU-e in normals and untreated early stage B cell CLL patients in a methylcellulose colony assay. Normal null cell cultures grew significantly more BFU-e than CLL null cell cultures. Addition of autologous T cells to normal or CLL null cells significantly increased BFU-e only in normals. Allogeneic coculture of T cells from CLL patients with null cells from normals yielded normal responses of BFU-e in five of six cases. In contrast, allogeneic coculture of normal T cells with CLL null cells yielded a normal response in only one of six studies. Furthermore, adding increasing quantities of autologous or normal allogeneic T cells to CLL null cells did not augment the BFU-e response. Accounting for the expanded lymphocyte pool in CLL, BFU-e are decreased in concentration but the absolute number is normal or increased. The decrease in concentration could be secondary to expansion of the null cell fraction in CLL by pre-B cells. CLL T cells appeared to augment normal allogeneic PB BFU-e in a normal fashion, whereas, in several cases, CLL BFU-e were hyporesponsive to autologous or normal allogeneic T cells. It is therefore apparent that in untreated early stage B cell CLL, erythroid progenitor cells are present in the peripheral blood but are diluted in an expanded null cell compartment and may, in some cases, be hyporesponsive to T cell BPA. T cell BPA of CLL T cells in this early stage of disease is preserved.

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T cells and erythroid burst forming units in chronic lymphocytic leukemia

Socinski

Ershler

1984

American J Hematol

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The Effects of X-irradiationin Vitroon Subpopulations of Human Lymphocytes

Szczylik¹,

Wiktor-Jedrzejczak²

1981

International Journal of Radiation Biology and Related Studies

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Human peripheral blood lymphocytes isolated using a Ficoll-Uropolinum gradient were exposed to between 1 and 25 Gy X-rays and were cultured for period of up to 72 hours. Before irradiation and after 2, 24, 48 and 72 hours total numbers of surviving cells per ml of culture were determined as well as the frequencies of cells spontaneously forming rosettes (E) and active rosettes (AE) with sheep red blood cells, cells bearing receptor for activated complement (EAC) and cells spontaneously forming rosettes with mouse red blood cells (ME). Irrespective of the duration of in vitro culture, the radiosensitivity of the subpopulations of human lymphocytes increased in the order E less than EAC = ME less than AE rosette forming cells. Calculation of the frequencies of surviving cells, null with respect to the surface markers (E and EAC), showed that disappearence of rosette-forming cells under the influence of radiation was largely due to the shedding of their receptors and not exclusively to cell death. It is suggested that the extreme radiosensitivity of the subpopulation of T lymphocytes capable of AE rosette formation, if confirmed by in vivo studies, may possess diagnostic significance in persons accidentally exposed to radiation.

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Proportions of Mouse Erythrocyte Rosette-Forming Lymphocytes, Immunoglobulin-Bearing Cells and E Rosettes in Patients with Lymphoproliferative Diseases

Cited by 2 publications

References 3 publications

T cells and erythroid burst forming units in chronic lymphocytic leukemia

T cells and erythroid burst forming units in chronic lymphocytic leukemia

The Effects of X-irradiationin Vitroon Subpopulations of Human Lymphocytes

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