Proposal for a measurement of the momentum dependence of the difference in forward scattering amplitudes of K and anti-K

Carithers, W.; Nygren, D. R.; Columbia, U British; Steinberger, J.; Dorfan, D. E.; Heusch, C.; Presccot, C.; Uc, Santa Cruz; Gelfand, N.; Kleinknecht, K.; Heidelberg, U; Wahl, H. D.

doi:10.2172/899062

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“…A similar analysis using SaVanT and selected tissues from the GTEx database also was performed. 37 Unlike GEDIT, SaVanT outputs scores rather than the percentages of cell populations, and the scores do not usually add up to 1. Using a built-in functionality, analysis of variance for significant differences between tissue abundances, demonstrated a significantly higher abundance of skeletal and esophageal muscle signature in the normal tissue compared with both tumor biopsies (see Supporting Fig.…”

Section: Apg-157 Treatment Results In An Alteration In the Gene Exprementioning

confidence: 99%

A randomized, phase 1, placebo‐controlled trial of APG‐157 in oral cancer demonstrates systemic absorption and an inhibitory effect on cytokines and tumor‐associated microbes

Basak

Bera

Yoon

et al. 2020

Cancer

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Background Although curcumin's effect on head and neck cancer has been studied in vitro and in vivo, to the authors' knowledge its efficacy is limited by poor systemic absorption from oral administration. APG‐157 is a botanical drug containing multiple polyphenols, including curcumin, developed under the US Food and Drug Administration's Botanical Drug Development, that delivers the active components to oromucosal tissues near the tumor target. Methods A double‐blind, randomized, placebo‐controlled, phase 1 clinical trial was conducted with APG‐157 in 13 normal subjects and 12 patients with oral cancer. Two doses, 100 mg or 200 mg, were delivered transorally every hour for 3 hours. Blood and saliva were collected before and 1 hour, 2 hours, 3 hours, and 24 hours after treatment. Electrocardiograms and blood tests did not demonstrate any toxicity. Results Treatment with APG‐157 resulted in circulating concentrations of curcumin and analogs peaking at 3 hours with reduced IL‐1β, IL‐6, and IL‐8 concentrations in the salivary supernatant fluid of patients with cancer. Salivary microbial flora analysis showed a reduction in Bacteroidetes species in cancer subjects. RNA and immunofluorescence analyses of tumor tissues of a subject demonstrated increased expression of genes associated with differentiation and T‐cell recruitment to the tumor microenvironment. Conclusions The results of the current study suggested that APG‐157 could serve as a therapeutic drug in combination with immunotherapy. Lay Summary Curcumin has been shown to suppress tumor cells because of its antioxidant and anti‐inflammatory properties. However, its effectiveness has been limited by poor absorption when delivered orally. Subjects with oral cancer were given oral APG‐157, a botanical drug containing multiple polyphenols, including curcumin. Curcumin was found in the blood and in tumor tissues. Inflammatory markers and Bacteroides species were found to be decreased in the saliva, and immune T cells were increased in the tumor tissue. APG‐157 is absorbed well, reduces inflammation, and attracts T cells to the tumor, suggesting its potential use in combination with immunotherapy drugs.

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Section: Apg-157 Treatment Results In An Alteration In the Gene Exprementioning

confidence: 99%

A randomized, phase 1, placebo‐controlled trial of APG‐157 in oral cancer demonstrates systemic absorption and an inhibitory effect on cytokines and tumor‐associated microbes

Basak

Bera

Yoon

et al. 2020

Cancer

View full text Add to dashboard Cite

show abstract

Proposal for a measurement of the momentum dependence of the difference in forward scattering amplitudes of K and anti-K

Cited by 1 publication

References 0 publications

A randomized, phase 1, placebo‐controlled trial of APG‐157 in oral cancer demonstrates systemic absorption and an inhibitory effect on cytokines and tumor‐associated microbes

A randomized, phase 1, placebo‐controlled trial of APG‐157 in oral cancer demonstrates systemic absorption and an inhibitory effect on cytokines and tumor‐associated microbes

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