Proposal for revision of the European Laryngological Society classification of endoscopic cordectomies

Remacle, Marc; Haverbeke, Christophe Van; Eckel, Hans Edmund; Bradley, Patrick J.; Chevalier, Dominique; Djukić, Vojko; Vicentiis, Marco de; Friedrich, Gerhard; Olofsson, Jan; Peretti, Giorgio; Quer, Miquel; Werner, Jochen A.

doi:10.1007/s00405-007-0304-2

Cited by 43 publications

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“…The objective of the present prospective study was to assess the functional outcome after cordectomy multidimensionally and longitudinally with respect to the morphological status of the glottis, the voice production mechanism as seen in stroboscopy, voice quality assessed by different parameters including the self-perception of the patient as evaluated by a questionnaire [Voice Handicap Index (VHI) 12 in German], maximal phonation time (MPT), Göttingen Hoarseness Diagram (GHD) and phonetogram.…”

Section: Introductionmentioning

confidence: 99%

Long-Term Functional Outcome after Unilateral Cordectomy

Keilmann¹,

Napiontek²,

Engel³

et al. 2010

ORL

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Purpose of the Study: Our aim was to longitudinally analyze the vocal outcome after endoscopic CO₂ laser resection of early glottic carcinoma. Procedures: Sixteen patients treated with laser surgery for T1 or T2 tumors of the vocal cords received voice therapy and were examined 1, 2, 3, 4.5, 6 and 12 months postoperatively. Besides videolaryngostroboscopy, each examination included history, phonetogram of the speaking and the singing voice, language-specific hoarseness diagram and a questionnaire (Voice Handicap Index 12 in German). Results: Objective parameters demonstrated a broad variability with a slight tendency of improvement over time. For the maximal phonation time a nearly constant improvement was seen. After an initial improvement deterioration for subjective assessment in the Voice Handicap Index was noted in most patients 3–6 months postoperatively. Conclusions: The functional outcome after cordectomy is variable. Message of the Paper: Discrepancies between objective findings and patient satisfaction over time have to be considered after cordectomy.

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Section: Introductionmentioning

confidence: 99%

Long-Term Functional Outcome after Unilateral Cordectomy

Keilmann¹,

Napiontek²,

Engel³

et al. 2010

ORL

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“…Several Authors agree that all parameters of the GIRBAS system and VHI score have a sufficient level of reliability in clinical practice to rate different grades of dysphonia (11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25).…”

Section: Discussionmentioning

confidence: 99%

Comparison of Subjective and Objective Tools in Transoral Laser Cordectomy for Early Glottic Cancer: Importance of Voice Handicap Index

Stomeo

Tosin

Morolli

et al. 2013

Int J Immunopathol Pharmacol

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Several studies in recent years have already reported good oncologic results with laser microsurgery in the treatment of early glottic carcinoma. We conducted a longitudinal voice evaluation, in patients with early glottic cancer who underwent transoral laser cordectomy, in order to assess the voice quality outcome and its relationship with objective and subjective (voice handicap index questionnaire and GIRBAS scale) means. Twenty-four previously untreated patients underwent transoral laser cordectomy for early glottic cancer. All patients underwent subjective and objective voice assessment according to the multidimensional voice protocol recommended by the European Laryngological Society including acoustic, perceptual and stroboscopic analysis combined to patient self assessment of voice (voice handicap index-VHI). These evaluations were performed before treatment and 6 months after the treatment. Vocal fold healing was complete in all cases by 6 months following surgery. Main voice parameters (subjective and objective) resulted improved at the 6-month control after surgery. In particular, voice handicap index (VHI) and GIRBAS scale resulted reliable for voice assessment and for the postoperative follow-up. In conclusion, VHI, GIRBAS, multidimensional voice program (MDVP) and spectroacoustic parameters showed a close trend in the present study, and this confirms the validity of the voice analysis performed by each tool.

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“…The patients had been previously treated by excisional biopsy, namely type I cordotomy/cordectomy, according to the classification of the Working Committee, European Laryngological Society (11,12), using 'cold' microinstruments and/or CO 2 Acublade 400 Lumenis laser, Sharplan 40C and Zeiss surgical microscope during microlaryngoscopy.…”

Section: Methodsmentioning

confidence: 99%

Chemoprevention using folic acid for dysplastic lesions of the larynx

Mesolella

Iengo

Testa

et al. 2017

Molecular and Clinical Oncology

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Abstract. Folate deficiency may be directly associated with carcinogenesis. Folate supplementation may reduce the risk of progression in a mucosa that is already genetically altered. The aim of the present study was to determine the role of folic acid in the treatment of mild and moderate laryngeal dysplasia recurring after surgery. The data obtained by laryngoscopy, measurement of serum folate levels and functional vocal assessment with the GIRBAS scale and VHI questionnaire were compared in patients who had received folic acid with a homogeneous group of patients with dysplasia who had not undergone any therapy. A total of 24 patients suffering from recurrence of mild or moderate laryngeal dysplasia (n=12, group A) were treated with 400 mg folic acid per os, once daily for 6 months. The patients in group B (n=12) received no treatment and were used as the control group. In group A, 7 (58%) patients exhibited a complete response, with clinically evident regression of leukoplakia, 3 (25%) displayed a partial decrease in the lesions with reduced volume of the area involved, whereas 2 patients exhibited no change. As regards patients in control group B, 8 (67%) exhibited no change, in 1 case there was a spontaneous regression, and in 3 (25%) there was disease progression with suspected malignant transformation, leading to repeat surgery. Therefore, folate deficiency may be considered to be a factor predisposing to precancerous lesions, and dietary folate supplementation may prevent and reduce the emergence of cancer. IntroductionCarcinogenesis is a multistep process including genetic alterations that develop over time, and it is associated with metabolic alterations that may promote neoplastic progression (1).Metabolic processes that use folates interfere with the synthesis, repair and methylation of DNA, as they are involved in the synthesis of purine and of pyrimidine bases and serve as methyl donors in the methionine cycle (2).Folate deficiency encourages the assimilation of uracil in the DNA, which causes a genomic instability characterized by the formation of single and double breaks in the DNA filaments, chromosomal breakages and the formation of micronuclei (2).It is obvious, therefore, that folate deficiency may be directly implicated in promoting carcinogenesis (3,4). The chronological succession of certain types of metaplasia of the laryngeal epithelium with laryngeal cancer may identify a group of lesions that are defined as 'precancerous' (5).Several events that take place during the transformation of precancerous lesions to cancer may be controlled and even reversed by removing the possible trigger factors (e.g., discontinuing smoking and following a balanced diet) and by using carcinogenesis inhibitors (chemoprevention) (6). Chemoprevention is the use of chemical or natural substances to reverse, suppress or prevent conversion of precancerous to invasive lesions (7). At this time, chemoprevention may be defined as the use of agents to prevent the appearance of precancerous lesions, or delay or revers...

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Proposal for revision of the European Laryngological Society classification of endoscopic cordectomies

Abstract: We apologize for any inconvenience caused.The online version of the original article can be found at http://dx

Cited by 43 publications

References 0 publications

Long-Term Functional Outcome after Unilateral Cordectomy

Long-Term Functional Outcome after Unilateral Cordectomy

Comparison of Subjective and Objective Tools in Transoral Laser Cordectomy for Early Glottic Cancer: Importance of Voice Handicap Index

Chemoprevention using folic acid for dysplastic lesions of the larynx

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