2008
DOI: 10.1248/bpb.31.1773
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Proposal of Membrane Transport Mechanism of Protein-Unbound Ulifloxacin into Epithelial Lining Fluid Determined by Improved Microdialysis

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Cited by 8 publications
(5 citation statements)
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“…In addition to the physical presence, there is also a sliding friction on the respiratory epithelium caused by the respiration, which makes the impact of the membrane even greater. Previous MD studies in pigs and rats have not studied the effects of the MD membrane on the respiratory epithelium . For drugs with a low penetration into PELF, there might be a risk of over‐interpretation of PELF distributions, if the integrity of the respiratory epithelium is impaired.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…In addition to the physical presence, there is also a sliding friction on the respiratory epithelium caused by the respiration, which makes the impact of the membrane even greater. Previous MD studies in pigs and rats have not studied the effects of the MD membrane on the respiratory epithelium . For drugs with a low penetration into PELF, there might be a risk of over‐interpretation of PELF distributions, if the integrity of the respiratory epithelium is impaired.…”
Section: Discussionmentioning
confidence: 99%
“…Nonetheless, there are only few published studies of antibiotic drug sampling in PELF by MD, and they are performed in rats. Studies in rats have shown that the aminoglycosides gentamicin and tobramycin have a relatively poor penetration to PELF (0.4 and 0.6), whereas the fluoroquinolone ulifloxacin has high penetration (2.9) . Physiology, anatomy and immunology of the porcine lung are reported to be more similar to man than the murine lung .…”
mentioning
confidence: 99%
“…Nevertheless, there are published reports with separate data on hydrogen peroxide concentration in BALF and on alveolar lining fluid volume. In normal human lungs, alveolar lining fluid volume fluctuates within the range of 0.2–2.0 mL [ 22 – 26 ], while in rats this volume has been found to be within the range of 0.03–0.26 mL [ 27 29 ]. Since commonly used volume of liquid for bronchoalveolar lavage in humans is 100 mL and 5 mL in rats, the expected dilution factor is likely to be ~100 in normal lungs [ 30 ].…”
Section: Sources Of H 2 O 2 mentioning
confidence: 99%
“…It has been reported as a minimally invasive method by some authors [6], but others have pointed out the pathophysiological changes taking place around the lD membrane [7][8][9]. Intrabronchial lD is a relatively unexplored application and has been used for quantification of antibiotics in rats and pigs [10][11][12] and for cytokine measurements in pigs [13,14].…”
mentioning
confidence: 99%