Proposal of novel staging system CNM (Crohn’s primary site, nodes, mesentery) to predict postoperative recurrence of Crohn’s disease

Abstract

scopic/clinical/surgical recurrence. So, recurrence in postoperative CD is primarily "relapse" or "persistent CD" rather than true recurrence. Among the histological features predicting recurrence in postoperative CD, the most commonly studied factor is positive resection margins. Microscopic positive resection margin increases the risk of clinical, surgical, and early recurrence (<12 months) by 2-, 9-, and 6-fold, respectively (Table 1). 1 Similarly, a retrospective study has shown that the inclusion of mesentery at ileocolonic resection in CD reduces the surgical recurrence rate substantially (40% to 2.9%). 2 However, the study results are confounded by different follow-up times and concerns regarding a higher risk of postoperative complications due to vascular compromise. 3 Hence, this is currently studied in randomized controlled trials (RCTs). 4 My-